树脂吸附血液灌流治疗重度有机磷中毒的临床研究  

The clinical research on resin hemoperfusion treating patients with severe organophosphate poisoning

作　　者：高全杰[1] 史忠[1] 李霞[1] 周坤[1] 

机构地区：[1]第三军医大学新桥医院,重庆400037

出　　处：《重庆医学》2008年第22期2520-2521,共2页Chongqing medicine

摘　　要：目的探讨树脂吸附血液灌流治疗急性重度有机磷中毒的临床疗效。方法将2000年2月至2008年3月收治的116例符合急性重度有机磷中毒诊断标准的患者按治疗方法不同分组,比较两组间衡量有机磷中毒疗效的主要指标差异和树脂吸附血液灌流的不良反应。结果树脂吸附血液灌流组较对照组(常规治疗)患者昏迷苏醒时间、胆碱酯酶活力恢复时间明显缩短,阿托品用量减少,病死率下降,治疗相关性不良反应减少。血液灌流后未发生灌流致热反应,灌流前后血色素、血小板及凝血因子无明显减少现象。结论应用树脂吸附血液灌流治疗急性重度有机磷中毒疗效好且不良反应较少。Objective To observe the clinical effect of HA type resin hemoperfusion apparatus on acute severe organophospbate poisoning （AsoP）. Methods One hundred and sixteen patients with ASOP enrolled in this study were allocated to two groups： HA-type resin hemoperfusion apparatus treatment group （HP group） and traditional treatment （without hemoperfusion treatment） group （non-HP group）. The differences in principal indices and adverse effect of resin hemoperfusion were compared between the two groups. Results In HP group, the palinesthesia time and cholinesterase activity recovery time were obviously shorter than those of nowHP group （P〈0.01） ;the total dose of atropine administration decreased obviously （P〈0.01） ;the mortality and side reaction incidence rate decreased obviously, too. No perfusion induced pyrogen reaction occurred. There were no significant differ ences in Hb,platelet count and blood coagulation factors. Conclusion Compared with the traditional treatment of ASOP,the HA type resin hemoperfusion apparatus treatment is more effective and safer.

关 键 词：急性重度有机磷农药中毒 血液灌流 对比研究 

分 类 号：R595.4[医药卫生—内科学] R459.4[医药卫生—临床医学]