阿米替林中毒患者血药浓度变化及其对预后的影响  

Variation of blood concentration of amitriptyline and its effect on prognosis in patients with amitriptyline intoxication

作　　者：何盛琴[1] 李晓萍[1] 熊建琼[1] 

机构地区：[1]第三军医大学西南医院ICU,重庆400038

出　　处：《重庆医学》2008年第22期2529-2530,共2页Chongqing medicine

摘　　要：目的研究阿米替林中毒患者血药浓度变化及其对预后的影响。方法阿米替林中毒患者38例,入院后除常规治疗外,部分患者同时行血液灌流治疗,并采用反相高效液相色谱法于入院时及入院后3h测定血浆阿米替林浓度。结果血液灌流后血浆阿米替林浓度与灌流前相比显著下降〔由(0.75±0.21)μg/mL降至(0.32±0.14)μg/mL〕,中毒症状明显改善。结论血液灌流能显著加快血中阿米替林的清除。Objective To study the variation of blood concentration of amitriptyline and its effect on prognosis in patients with amitriptyline intoxication. Methods Thirty eight patients with amitriptyline intoxication were involved and some of them were per- formed with hemoperfusion besides the conventional therapy. The serum concentration of amitriptyline was measured with reverse phase high performance liquid chromatography on admission and 3 h after hospitalization. Results The serum concentration of amitriptyline was significantly decreased from （0.75±0.21）μg/mL to （0.32±0.14）μgg/mL after hemoperfusion. The symptoms and signs of severe arnitriptyline intoxication were obviously improved. Conclusion Hemoperfusion can eliminate serum amitripyline effectively.

关 键 词：血液灌流 阿米替林 中毒 血药浓度 

分 类 号：R595.4[医药卫生—内科学] R459.4[医药卫生—临床医学]