健康成人二氧化碳通气当量与生理死腔的相关性研究  

Correlation between ventilatory equivalent for carbon dioxide and physiologic dead space at rest and during exercise in health adults

作　　者：肖瑶[1] 王浩彦[2] 徐秋芬[1] 樊静[1] 张玲[1] 

机构地区：[1]首都医科大学附属北京安贞医院呼吸科,北京100029 [2]首都医科大学附属北京友谊医院呼吸科

出　　处：《心肺血管病杂志》2008年第6期330-332,共3页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:通过健康成人二氧化碳通气当量(EqCO2)和生理死腔/潮气量(VD/VT)比率的相关性探讨,用无创的方法代替有创的方法研究呼吸生理。方法:28例受试者行心肺运动试验,同步实时测定分钟通气量(VE)和二氧化碳产生量(VCO2),计算出静态二氧化碳通气当量(EqCO2rest)、无氧阈二氧化碳通气当量(EqCO2AT)及最大运动状态下二氧化碳通气当量(EqCO2max)。并分别在运动前及运动高峰时抽取动脉血,根据改良Bohr的公式,得出实际生理死腔/潮气量比率(VD/VT)。结果:正常人静态时EqCO2rest与VD/VTrest有显著相关关系(r=0.601,P=0.011);运动高峰时EqCO2max与VD/VTmax无相关性(r=-0.223,P=0.334),且EqCO2AT和EqCO2max较EqCO2rest明显下降,差异有统计学意义(P<0.001),EqCO2max与EqCO2AT比较也有下降,但差异无统计学意义(P=0.417)。结论:正常成人静息状态下用无创方法测定EqCO2可反映实际VD/VT。Objective： To evaluate the feasibility of the ventilatory equivalent for carbon dioxide （EqCO2 ） substituting for the actual ratio of physiologic dead space to tidal volume （VD/VT） by means of the correlation between EqCO2 and VD/VT at rest and during exercise in healthy adults. Method： Cardiopulmonary exercise testing was performed in 28 healthy adults. Minute ventilation （VE） and carbon dioxide output （VCO2 ） were measured continuously on the breath-by-breath mode. EqCO2 was measured according to equation of VE/VCO2 Arterial blood samples were drawn both at rest and maximal exercise. The actual VD/VT was measured according to Bobr＇ s equation. Result：There was significant correlation between the actual VD/VT and EqCO2 at rest （ r = 0.601, P = 0.011） and no significant correlation at maximal exercise（ r = - 0.223, P = 0.334）, EqCO2 decreased as work rate increased during exercise. EqCO2 significantly decreased at anaerobic threshold （AT） and at maximal exercise compared with that at rest （P 〈 0.001 ）. There was no significant differences between EqCO2 at AT and at maximal exercise （ P = 0,417）. Conclusion： EqCO2 can be used as a substitute for actual VD/VT in healthy adults at rest.

关 键 词：生理死腔/潮气量 二氧化碳通气当量 运动 

分 类 号：Q472[生物学—生理学]