子痫前期患者血肾功能测定及临床意义  

Changes of Biochemical Index of Renal Function in Pre-eclampsia Women and Clinical Value of the Changes

作　　者：刘永梅 张国英 

机构地区：[1]东营市人民医院妇产科,山东东营257091

出　　处：《中国医疗前沿（学术版）》2008年第9期36-37,共2页China Healthcare Innovation

摘　　要：目的探讨妊娠高血压病子痫前期患者血肾功能指标变化及其与围产儿结局的关系。方法回顾性分析166例子痫前期患者的肾功能指标及围产儿的结局,与同期100例正常分娩者比较,并在轻、重度两组子痫前期患者之间进行了比较。结果子痫前期组新生儿体重显著低于正常妊娠组(p<0.001),窒息发生率、围产儿死亡率明显高于正常妊娠组(p=0.013,p=0.033)。妊高征患者UA、Gr显著高于正常组(p=0.001,p=0.009),其中以UA增高最为敏感,且与围产儿预后关系密切。结论肾功能尤其是血尿酸的变化可以估计子痫前期患者病情发展变化,与围产儿结局密切相关。Objective To investigate the changes of biochemical of renal function in Pre-eclampsia women and it＇s relationship with pregnancy outcome. Methods Serumuricacid （UA）, Creatinine （Cr） and blood ureanitrogen （BUN） were retrospective analyzed in 166 Pre-eclampsia women comparing with 100 normal late-pregnancy women and the relationship between these biochemical indices and pregnancy outcomes were compared in the two groups. Results There was a significant higher depression of birth weight （p〈0.001） in eclampsism group while significant increase in perinatal mortality rate（p=0.033） and asphyxia incidence rate（p=0.013） than in normal pregnancy group. The blood level of UA and Cr, especially the former in eclampsism group were significant higher than in normal pregnancy group （p=0.001,p=0.009）. Conclusion The changes of biochemical index of renal function, especially UA, appear to be useful in forecasting the progression of pregnancy-induced hypertension women. As one of sensitive indices to examine the dysfunction of kidney, UA has relationship with pregnancy outcome.

关 键 词：子痫前期 肾功能 高尿酸血症 围产儿 

分 类 号：R714.244[医药卫生—妇产科学]