解偶联蛋白2与2型糖尿病关系研究进展  

PROGRESS OF STUDIES ON THE RELATIONSHIP BETWEEN UNCOUPLING PROTEIN-2 AND TYPE 2 DIABETES MELLITUS

作　　者：何柳[1] 宋岩[1] 胡永华[1] 

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100083

出　　处：《现代预防医学》2008年第22期4501-4503,4508,共4页Modern Preventive Medicine

基　　金：国家重点基础研究发展计划(973)子项目(2006CB503903)

摘　　要：解偶联蛋白2在体内广泛分布,与机体能量代谢和胰岛素分泌密切相关,并参与脂质过氧化的体内调节。因此,解偶联蛋白2与2型糖尿病关系是目前2型糖尿病病因学研究的热点之一。本文就与解偶联蛋白2相关的2型糖尿病发病机制以及遗传流行病学的研究现状作一综述。Research on the relationship between uncoupling protein-2 （UCP2） and type 2 diabetes melLitus is now becoming an attractive, area in exploring the mechanism of type 2 diabetes mellitus. UCP2. which distributes widely in human body and participates in the regulation of lipid peroxidation, is related to energy metabolism and glucose-induced insulin secretion. Therefore, study on the relationship between polymorphism of UCP2 gene and type 2 diabetes mellitus becomes an important branch of further researches. This article reviews the research progress of the relationship between UCP2 and type 2 diabetes mellitus.

关 键 词：2型糖尿病 解偶联蛋白2 基因多态性 

分 类 号：R587.1[医药卫生—内分泌]