高三尖杉酯碱对大鼠佐剂性关节炎SP及IL-1β、TNF-α影响的实验研究  

Experimental Study on Effect of Homoharringtonine on SP,IL-1β and TNF-α in Rats of Adjuvant Arthritis

作　　者：冯红德[1] 康海英[1] 宋欣伟[1] 吴玲燕[1] 孙伟[1] 戴巧定[1] 

机构地区：[1]浙江中医药大学第一临床医学院,杭州310053

出　　处：《浙江中医药大学学报》2008年第6期726-729,共4页Journal of Zhejiang Chinese Medical University

基　　金：浙江省中医药管理局资助项目(No:2006Y001)~~

摘　　要：[目的]观察高三尖杉酯碱对大鼠佐剂性关节炎模型(AA)的作用。[方法]采用大鼠佐剂性关节炎模型,以雷公藤多甙作为阳性药物对照,观察高三尖杉酯碱对大鼠佐剂性关节炎模型SP及IL-1β、TNF-α的影响。[结果]经高三尖杉酯碱,雷公藤多甙干预后,AA大鼠血清与滑膜中TNF-α、IL-1β含量,以及血浆,滑膜中SP含量均明显下降。[结论]高三尖杉酯碱有与雷公藤多甙相类似的抗炎作用,可能是通过明显抑制AA大鼠血清与滑膜中TNF-α、IL-1β含量,以及血浆、滑膜中SP含量的分泌和释放,起到治疗AA大鼠关节炎作用的。[Objective] To observe the effect of Homoharringtonine on Adjuvant Arthritis Rats. [Methods]Observe the effect of Homoharringtonine on Adjuvant Arthritis Rats＇ SP, IL-1β and TNF-α;we take the Adjuvant Arthritis Rats as model and Tripterygium wilfordii polycoside was the positive group. [Results]The Homoharringtonine and Tripterygium wilfordii polycoside group＇s level of TNF-α, IL-1β in the serum and synovial membrane decreased instructively,and their dose of SP in the plasma and synoviat membrane was suppressed obviously too. [Conclusion]Homoharringtonine has the effect of anti-inflammation,it may treat the Adjuvant Arthritis Rats through reducing the dose of TNF-α,IL-1β in the serum and synovial membrane,inhibiting the secretion and releasing SP in the plasma and synovial membrane.

关 键 词：高三尖杉酯碱 大鼠佐剂性关节炎 SP IL-1β、TNF-α 

分 类 号：R285.5[医药卫生—中药学]