2型糖尿病患者周围神经病变与心率变异性的关系  

Relationship between heart rate variability and peripheral neuropathy in patients with type 2 diabetic mellitus

作　　者：陈雪婷[1,2] 潘文志[1] 刁爱新 

机构地区：[1]复旦大学附属中山医院心内科,上海200032 [2]江苏省常熟市第五人民医院心内科 [3]山东枣庄矿业集团公司中心医院心内科

出　　处：《临床内科杂志》2008年第11期771-773,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨2型糖尿病患者周围神经病变(DPN)的危险因素及其与心率变异性的关系。方法对149名2型糖尿病患者行常规血生化、肌电图及心率变异性检测,分析2型糖尿病患者周围神经病变的危险因素,探讨其与心率变异性的关系。结果DPN发生率为52.35%(78/149);DPN组与非DPN组比,年龄大、糖尿病病程长、空腹血糖和甘油三酯高(P<0.05);Logitstic多元逐步回归分析显示年龄、糖尿病病程、空腹血糖、糖化血红蛋白和血总胆固醇与DPN独立相关(P<0.05);DPN组心率变异性各指标均低于非DPN组,其中24小时内相邻正常窦性心率R-R间期的标准差(SDNN)、全程中每5分钟R-R间期均值的标准差(SDANN)、全程中每5分钟R-R间期标准差的平均值(SDNNI)差异有统计学意义(P<0.05)。结论2型糖尿病患者周围神经病变与年龄、长期高血糖及高血脂有关。2型糖尿病患者周围神经病变患者心率变异指数常下降。Objective To investigate the relationship between heart rate variability （HRV）and peripheral neuropathy（DPN） in patients with type 2 diabetic mellitus. Methods A total of 149 patients with type 2 diabetes were examined. The examination included regular blood biochemical test, an assess- ment of nerve conduction velocity and a HRV study. Results The prevalence of DPN was 52.35%. DPN was independently associated with age, duration of diabetes, FBG（ fast blood glucose）and TC （serum total cholesterol） （P 〈0.05 ）. The SDNN, SDANN and SDNNI of HRV in DPN group were significantly lower than those in non-DPN group （P 〈 0.05 ）. Conclusion Reduction of HRV may predict the occurrence of diabetic peripheral neuropathy.

关 键 词：2型糖尿病 周围神经病变 心率变异性 

分 类 号：R587.1[医药卫生—内分泌] R541[医药卫生—内科学]