抗心磷脂抗体在原发性干燥综合征中的临床意义  

Frequency and Significance of Anticardiolipin Antibodies in Patients with Primary Sjgren's Syndrome

作　　者：李博[1,2] 胡秋侠[1,2] 何伟珍[1,2] 汪迅[1,2] 张丽君[1,2] 李剑松[1,2] 郭粉莲[1,2] 叶志中[1,2] 庄俊汉[1,2] 

机构地区：[1]深圳市第四人民医院香蜜湖风湿病分院 [2]广东医学院深圳风湿病研究所,518040

出　　处：《临床内科杂志》2008年第11期779-781,共3页Journal of Clinical Internal Medicine

基　　金：深圳市医学重点学科建设基金资助项目(编号:2005C10)

摘　　要：目的探讨抗心磷脂抗体(aCL)在原发性干燥综合征(pSS)患者中的意义。方法用酶联免疫吸收法(ELISA)检测pSS患者血清中的aCL,记录并分析pSS患者的临床资料及实验室检查结果。结果aCL在pSS患者中的阳性率为28%,主要是IgG-aCL及IgM-aCL。与aCL阴性的pSS患者相比较,aCL阳性的pSS患者中皮肤血管炎、甲状腺疾病及原发性胆汁性肝硬化、ANA阳性及高丙球蛋白血症更多见(P<0.05)。结论aCL在pSS的发病中可能具有一定的作用,对于aCL阳性的pSS患者,应注意有无并发甲状腺疾病及原发性胆汁性肝硬化等自身免疫性疾病。Objective To ascertain the prevalence and clinical significance of anticardiolipin （aCL） antibodies in Chinese patients with primary Sjogren＇ s syndrome （pSS） according to revised European criteria. Method The aCL antibodies were measured by the enzyme-linked immunoassay （ELISA）. Clinical and serologic manifestations of patients with pSS were tested and recorded. Results ACL antibodies were found in 26 （28%） patients and were mainly IgG-aCL and IgM-aCL （IgG-aCL in 14 patients, IgM-aCL in 9 patients and IgA-aCL in 3 patients）. Cutaneous vasculitis and concurrent autoimmune disease （thyroidal disease, primary biliary cirrhosis） were more frequent in the aCL-positive group than in the aCL-negative group （P 〈 0.05 ）. Patients with positive aCL also presented a higher prevalence of positive ANA and hypergammaglobulinemia（P 〈 0.05 ）. Conclusion ACL antibodies may play a pathogenic role in patients with pSS. Detection of aCL antibodies in patients with pSS may indicate rheumatlogist to find if concurrent autoimmune diseases （ thyroidal disease, primary biliary cirrhosis） exsist.

关 键 词：抗心磷脂抗体 干燥综合征 原发性 

分 类 号：R593.2[医药卫生—内科学]