枯草杆菌、肠球菌二联活菌多维颗粒剂联合鲁米那钠治疗母乳性黄疸临床观察  

Clinical Investigation on the Effect of Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines and Phenobarbital Sodium in the Treatment of Breast-milk Jaundice

作　　者：陈永秀[1] 陈莉娜[1] 

机构地区：[1]四川大学华西第二医院儿科,四川成都610041

出　　处：《华西医学》2008年第2期263-264,共2页West China Medical Journal

摘　　要：目的:观察枯草杆菌、肠球菌二联活菌多维颗粒剂联合鲁米那钠治疗母乳性黄疸的疗效。方法:将60例母乳性黄疸患儿随机分为Ⅰ、Ⅱ组,各30例患儿。两组均维持母乳喂养,Ⅰ组同时给予枯草杆菌、肠球菌二联活菌多维颗粒剂及鲁米那钠治疗;Ⅱ组仅用鲁米那钠治疗。两组患儿均治疗7至14天,观察其黄疸消退情况、治疗前及治疗7天后血清胆红素水平变化。结果:服药后3天两组患儿黄疸均开始减轻,7天时I组33%、Ⅱ组20%的患儿黄疸消失;第14天时Ⅰ组93%、Ⅱ组63%的患儿黄疸消失。用药前,两组患儿血清胆红素水平无明显差异(P>0.05),用药7天后Ⅰ组胆红素水平较Ⅱ组明显降低(P<0.05)。结论:对母乳性黄疸患儿,联合使用枯草杆菌、肠球菌二联活菌多维颗粒剂及鲁米那钠,对改善症状和降低血清胆红素水平优于单用鲁米那钠,疗效显著。Objective：To investigate the effect of live combined bacillus subtilis and enterococcus faecium granules with multivitamines and phenobarbital sodium in the treatment of breast-milk jaundice.Methods：Sixty infants diagnosed as breast-milk jaundice were randomly divided into Group Ⅰ and Group Ⅱ,each group had 30 cases.Both groups continued to be fed with breast milk.Meanwhile,Group Ⅰ was given Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines and phenobarbital sodium simultaneously while Group Ⅱ was simply given phenobarbital sodium.Both groups were treated 7 to 14 days.The changes of patients＇ jaundice were observed,serum bilirubin levels were measured before and 7 days after the treatment.Results：Patients＇ jaundice began to alleviate 3 days after treatment.The percentage of patients whose jaundice disappear was 33% in Group Ⅰ,22% in Group Ⅱ7 days after the therapy and 93%,63% respectively at the 14th day of treatment.The serum bilirubin levels in both groups were comparable before the treatment（P〉0.05）,however the level was significantly lower in Group Ⅰ compared with Group Ⅱ7 days after the therapy（P〈0.05）.Conclusion：Combination of Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines and phenobarbital sodium in the treatment of breast-milk jaundice achieved better effects compared with single usage of phenobarbital sodium.

关 键 词：枯草杆菌、肠球菌二联活菌多维颗粒剂 鲁米那钠 母乳性黄疸 

分 类 号：R722.1[医药卫生—儿科]