FK506在肾移植术后爬行肌酐患者的替换应用  

Replacement Proposals of FK506 in Patients having Creeping Serum Creatinine after Renal Transplantation

作　　者：王莉[1] 卢一平[1] 唐科士[1] 何凡[1] 

机构地区：[1]四川大学华西医院泌尿科,四川成都610041

出　　处：《华西医学》2008年第3期494-495,共2页West China Medical Journal

摘　　要：目的：探讨肾移植术后免疫抑制剂替换应用的经验。方法：回顾性分析我院2003年~2007年收治的肾移植术后爬行肌酐的患者（35例）,观察患者由环孢素A转换为FK506方案治疗后肾功能的变化及其不良反应。结果：替换后总体有效率达91.43%,其中显效82.86%,经配对t检验替换前后肌酐差异P〈0.001,差异有统计学意义,替换后肌酐较替换前明显减低。结论：FK506在出现爬行肌酐时作为替换治疗手段,是有效、安全的方案。Objective：To discuss replacement proposals of immunosuppressive agent after renal transplantation.Methods：Retrospective analysis of 35 patients with creeping serum creatinine from 2003 to 2007 was carried out.Observe renal function and adverse effects after FK506 replaced CsA.Results：After transfer of FK506 the overall effective was 91.43%,significant effective was 82.86%,t-test P〈0.001,The difference was statistically significanly.Serum creatinine was significantly decreased after transfer treatment.Conclusion：FK506 was effective and safety transfer treatment when occurring creeping serum creatinine.

关 键 词：爬行肌酐 慢性移植肾功能丧失 

分 类 号：R699[医药卫生—泌尿科学]