水通道蛋白-5与鼻息肉手术疗效的相关性  

Correlation between aquaporin-5 expression and curative results of nasal polyp operations

作　　者：曹迎春 史学燕 李建东 王宗峰 李新功 

机构地区：[1]东营市人民医院耳鼻咽喉科,山东东营257091 [2]东营市人民医院病理科,山东东营257091

出　　处：《山东大学耳鼻喉眼学报》2008年第5期442-444,456,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的观察水通道蛋白-5(aquaporin-5,AQP5)在鼻息肉术后未复发及复发患者鼻息肉组织中的表达及分布,初步探讨AQP5在鼻息肉中的表达程度与鼻息肉手术疗效的相关性。方法选取鼻息肉患者63例,两侧病变以病重侧计,所有病例均在鼻内镜下行鼻息肉摘除及窦口开放术。取63例鼻息肉组织,用4%多聚甲醛固定,石蜡包埋,连续切片,应用HE染色和免疫组织化学技术检测AQP5在未复发和复发鼻息肉组织中的阳性细胞的表达,对AQP5表达程度和手术疗效进行相关性统计学分析。结果AQP5在鼻息肉术后未复发组中的阳性细胞表达显著降低,与复发组比较,差异有统计学意义(P<0.05)。结论AQP5的高表达可能与术后鼻息肉复发有一定关系;鼻息肉的AQP5的表达程度可以作为预测鼻息肉患者预后指标之一。Objective To observe the distribution and expression of aquaporin-5（AQP5） in recurrent nasal polyps and cured ones and to explore the relationship between AQP5 in nasal polyps and the curative results of nasal polyp operations.Methods Endoscopic sinus surgery was performed on 63 patients with nasal polyps who were followed up for 6 months.After the operations,nasal padding materials were removed at 48 hours,hormones were used for 1 to 2 months,saline was used for flushing the nostrils once daily for 1 to 3 months and the nasal cavity was cleaned up under nasal endoscopy once a week for 1 month,and then once every two weeks for 3 to 6months.AQP5 expression was determined by immunohistochemistry in the recurrent nasal polyp group and the cured group.Results The expression of AQP-5 positive cells was statistically significantly decreased in the recurrent nasal polyp group compared with the cured group（P〈0.05）.Conclusions Over-expression of AQP5 may influence the recurrence of nasal polyps and it might be used as an index for prognosis of nasal polyps after the operations.

关 键 词：鼻息肉 内窥镜检查 水通道蛋白 免疫组织化学 

分 类 号：R765.24[医药卫生—耳鼻咽喉科]