CT肺功能像素指数对COPD的肺功能评估及与肺功能的相关性分析  

Comparison of the diagnostic value of quantitative CT pixel indices and pulmonary function test in chronic obstructive pulmonary disease

作　　者：叶彩儿[1] 叶民[1] 吴碎英[1] 吴恩福[1] 陈伟建[1] 

机构地区：[1]温州医学院附属第一医院放射科,浙江温州325000

出　　处：《中国临床医学影像杂志》2008年第11期775-778,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:研究定量多层CT肺像素指数(PI)与肺功能实验(PFT)指标的相关性及对慢性阻塞性肺病(COPD)的肺功能评估。方法:COPD组48例和健康对照组28例,行平静呼吸下定量CT检查。CT及PFT检查均在1周内完成。利用CT肺功能Pulmo肺定量软件测定像素指数PI,分为-1024～-960,-960～-910,-910～-800,-800～-700,>-7005个区,分析PI与PFT指标间的相关性,并勾画出像素直方图。结果:PI与PFT指标存在相关性,且PI-960～-910与PFT相关性最好。轻中度组、重度组COPD与正常组相比,PI-960～-910均显著增加,PI-800～-700、PI>-700均显著减低(P<0.01),PI-1024～-960、PI-910～-800在正常组、轻中度组及重度组之间均存在差异(P<0.05)。结论:平静呼吸状态下CTPI与PFT相关,可用于评估肺功能状况,结合像素直方图变化反映COPD的严重程度。Objective： To assess the diagnostic value of quantitative CT pixel indices （PI）, correlated with pulmonary function test（PFT） in chronic obstructive puhnonary disease（COPD）. Materials and Methods： This study included 48 patients with COPD （slight-moderate group and severe group） and 20 normal controls. All subjects underwent CT scanning of the lungs with normal respiration and PFT within one week. PI were analyzed by pulmonary quantitative software Pulmo and the parameters PI included -1024--960, -960--910, -910--800, -800--700, 〉-700. Analyze the correlation between PI and PFT, draw histograms of lung attenuation. Results： There was correlation between PI and PFT, there was significant correlation between PI-960-910 and PFT. PI-960--910 significantly increased in slight-moderate group and severe group as compared to control group, while PI-800-700 and PI〉-700 were significantly decreased （P〈0.01）. PI-1024-960 and PI-910-800 were different in three groups （P〈0.05）. Conclusion： PI was correlated with those data of PFT in normal respiration, which can evaluate lung function, and was combined with image element histogram to reflect the degree of COPD paitent.

关 键 词：肺疾病 慢性阻寒性 体层摄影术 X线计算机 

分 类 号：R563[医药卫生—呼吸系统] R814.42[医药卫生—内科学]