罗红霉素联合敏感抗生素治疗铜绿假单胞菌生物被膜病的临床研究  

Clinical Study of Roxithromycin Combination with Sensitive Antibiotics in Pseudomonas Aeruginosa Biofilms Disease

作　　者：唐义平[1] 陈平[1] 

机构地区：[1]四川省医学科学院.四川省人民医院干部医疗科,四川成都610072

出　　处：《华西医学》2008年第4期801-803,共3页West China Medical Journal

摘　　要：目的:探索治疗铜绿假单胞菌(pseudomonas aeruginosa,PA)生物被膜病的临床方法。方法:82例PA生物被膜病患者随机分为治疗组和对照组。治疗组给予口服罗红霉素0.15Bid,同时联合应用一种对PA药敏试验敏感的抗生素。对照组仅给予一种对PA药敏试验敏感的抗生素。两组选用的对PA药敏试验敏感的抗生素有:头孢他啶3g静脉滴注Bid、哌拉西林-他唑巴坦6.75g静脉滴注Bid或头孢派酮-舒巴坦3g静脉滴注Bid。两组疗程均为2周。结果:治疗组症状、体征好转的平均天数以及体温降至正常、中性粒细胞比例恢复正常的平均天数均比对照组减少,两者差异有统计学意义(P<0.05)。治疗组的治愈率(68.3%)和总有效率(92.7%)均高于对照组的治愈率(34.1%)和总有效率(70.7%),两者差异有统计学意义(P<0.05)。结论:罗红霉素联合敏感抗生素治疗PA生物被膜病,疗效优于单用敏感抗生素。罗红霉素联合敏感抗生素为治疗PA生物被膜病提供了一种有效的方法。Objective：This clinical trial was designed to study the treatment of pseudomonas aeruginosa（PA） biofilms disease.Methods：A total of 82 patients with PA biofilms disease were randomly divided into trial group and control group.The trial group were treated with roxithromycin at a dose of 0.15 g twice a day orally and one kind of sensitive antibiotic to PA simultaneouly.The control group were treated with one kind of sensitive antibiotic to PA alone.The sensitive antibiotic including ceftazidime 3 g twice a day,piperacillin sodium-tazobactam sodium 6.75 twice a day or cefoperazone sodium-sulbactam sodium 3 g twice a day were chosed by an in vitro test for the sensitivity to PA.These three drugs were administered intravenously for 14 days.Results：The average days of complaints and physical signs improved and the average days of the neutrophil counts and temperature recovered to the normal level in the trial group were significantly shorter than those in the control group respectively （P〈0.05）.Both the cure rate（68.3%） and the total clinical efficacy rate （92.7%） of the trial group were significantly higher than the cure rate（34.1%） and the total clinical efficacy rate（70.1%） of the control group（P〈0.05）.Conclusions：The clinical efficacy of the combination of roxithromycin and sensitive antibiotic to treat PA biofilms disease was better than one kind of sensitive antibiotic alone.Such combination therapy with roxithromycin and sensitive antibiotic may be advantageous for treating PA biofilms disease.

关 键 词：铜绿假单胞菌 生物被膜病 罗红霉素 

分 类 号：R516[医药卫生—内科学]