拉米夫定治疗老年肝硬化合并肝源性糖尿病临床观察  

The Transformations of State in Aged patients Suffer from Hepatocirrhosis Incorporated with Diabetse were Observat through the Iamirudine Therapy

作　　者：薛建亚[1] 朱咏梅[1] 张迁[1] 童群燕[1] 

机构地区：[1]第二军医大学附属长海医院感染科,上海200433

出　　处：《医学研究杂志》2008年第11期81-82,共2页Journal of Medical Research

摘　　要：目的观察拉米夫定在治疗老年肝硬化合并肝源性糖尿病患者过程中对其临床病情影响。方法对36例老年肝硬化合并肝源性糖尿病患者临床病情特点、糖尿病病情与肝功能分级的关系、拉米夫定治疗对临床病情的影响等进行回顾性分析。结果36例老年肝硬化合并肝源性糖尿病患者中具典型糖尿病临床症状者较为少见(2.8%);发生自发性细菌性腹膜炎者较多见(61.1%);伴随着肝功能的恶化,血糖可出现明显异常,肝功能C级血糖重型增高可达42.9%,经拉米夫定等综合治疗肝功能有明显好转,其血糖水平亦可有所控制。结论老年肝硬化合并肝源性糖尿病其糖尿病的临床症状常不典型,血糖水平与肝硬化病情轻重呈正相关,拉米夫定治疗有利于肝功能的好转,亦有利于血糖的控制。Objective The transformations of clinical state in aged patients suffered from hepatoeirrhosis incorporated with diabetes were observed through the lamivudine therapy. Methods The clinieal state,state of diabetes related to the grade of liver function and the influence of clinical state by lamivncline treatment in 36 patients were analyzed. Results Those with representative symptom of diabetes were less observed （2.8%） in these 36 patients. The patients complicating with the spontaneous bacterial peritonitis had a high chance. The blood glucose level show obviously abnormas after the liver function got worse. With the liver function improved through combined therapy include lamivudine,the blood glucose level turned to a low level. Conclusion The clinical state in aged patients suffered from hepato- cirrhosis with H type diabetes is untypical. The blood glucose level appearances direct correlation with the condition of hepatocirrhosis. Treatments with lamivudine was favorable for control of blood glucose level and better liver function.

关 键 词：拉米夫定 肝硬化 临床分析 治疗方法 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]