载脂蛋白M的基因多态性与冠心病的相关性  

Association of apolipoprotein M gene polymorphism with coronary artery disease

作　　者：焦国庆[1] 苏伟强[1] 薛永生[1] 肖明第[2] 

机构地区：[1]南京医科大学附属无锡市第二人民医院胸心外科,无锡214002 [2]上海交通大学附属上海市第一人民医院心血管外科

出　　处：《江苏医药》2008年第11期1101-1103,共3页Jiangsu Medical Journal

摘　　要：目的探讨载脂蛋白M(ApoM)的基因多态性与冠心病的相关性。方法以聚合酶链反应-限制性内切酶片段多态性分析(PCR-RFLP)方法检测冠心病组(118例)和对照组(非冠心病患者225例)ApoM的基因多态性,以酶法测定血浆中脂质。结果与对照组相比,冠心病组ApoM基因-778位点等位基因C的频率增高(P<0.01)。多参数回归分析提示,基因型CC+CT的优势比(OR)为1.9(95%CI=1.1～2.9,P<0.01),等位基因C的OR为1.9(95%CI=1.3～3.2,P<0.01)。基因型CC+CT的研究人群中血清总胆固醇的水平明显高于TT基因型的人群。结论ApoM基因-778位点等位基因C是冠心病的危险因子,而且C等位基因与血清胆固醇相关。Objective To investigate the possible association of apolipoprotein M （ApoM） gene polyrnorphism with coronary artery disease （CAD）. Methods Study population consisted of 118 CAD patients and 225 unrelated subjects as the controls. Polymorphism of ApoM gene was detected by PCR-RFLP and serum lipid levels were measured enzymatically. Results CAD patients had an increased frequency of C allele on ApoM T-778C compared to the controls （P〈0. 01）. Further multivariable logistic regression analysis indicated that odds ratios （ORs） for all subjects with ApoM CC＋CT genotypes and those with ApoM C allele were 1.9 （95% CI=1. 1-2.9, P〈0. 01） and 1.9 （95 % CI= 1.3-3.2, P〈0.01）, respectively. The serum cholesterol levels were significantly higher in the individuals with CC or CT genotype than those with TT genotype in both CAD patients and the controls. Conclusion The present finding suggests that C allele at nucleotide-778 in ApoM gene is a risk factor for genetic susceptibility of CAD and is associated with the serum cholesterol levels.

关 键 词：载脂蛋白M 冠心病 基因多态 危险因子 

分 类 号：R543[医药卫生—心血管疾病]