冠心病患者氧化低密度脂蛋白自身抗体的变化  

The changes of autoantibody against oxidized low density lipoprotein in patients with coronary heart disease

作　　者：沈建昕[1] 张三明[2] 鲁翔[2] 

机构地区：[1]河北北方学院第一附属医院检验科,张家口075000 [2]南京医科大学第二附属医院心脏病科

出　　处：《江苏医药》2008年第11期1106-1107,共2页Jiangsu Medical Journal

摘　　要：目的探讨血清氧化低密度脂蛋白自身抗体(Ab-ox-LDL)与冠心病患者病变稳定性及病变程度的关系。方法根据临床诊断标准和冠状动脉造影结果,将60例患者分为非冠心病(CON)组、不稳定型心绞痛(UAP)组和稳定型心绞痛(SAP)组,采用ELISA法测定血清Ab-ox-LDL浓度。结果UAP组血清Ab-ox-LDL水平明显高于SAP和CON组(P<0.05),SAP组高于CON组(P<0.05);Ab-ox-LDL在UAP组和SAP组呈高度正相关(P<0.05)。结论血清Ab-ox-LDL与冠心病患者病变的严重程度和冠心病斑块的稳定性密切相关,在冠状动脉硬化进程中可能起着重要的作用。Objective To study the relationship of serum oxidezed low density lipoprotein autoantibody （Ab-ox-LDL） with the plaque stability and lesion degree of patients with coronary heart disease（CHD）. Methods According to clinical diagnostic criteria of CHD and coronary angiography, sixty patients were allocated into non-coronary heart disease（group C）, unstable angina pectoris（group UAP） and stable angina pectoris （group SAP）. Serum levels of Ab-ox-LDL were measured with enzyme-linked immunosorbent assay method. Results Serum Ab-ox-LDL was significantly higher in group UAP than that in group SAP and group C （P〈0. 05）, which was higher in group SAP than that in group C （P〈0.05）. Plasma Ab-ox-LDL and ox-LDL were positively correlated in patients of UAP and SAP group. Conclusion Serum Ab-ox-LDL level is closely related to the plaque stability and lesion degree in patients with CHD,may take a role in the proccess of atherosclerotic lesions.

关 键 词：氧化低密度脂蛋白 自身抗体 冠心病 

分 类 号：R541[医药卫生—心血管疾病]