萆薢柴胡颗粒联合阿齐霉素治疗NGU/MPC及其免疫调控的临床研究  

The Curative efficiency and its immune modulating effect of Bi-xie Chai-hu granule combined with Azithromycin in Ct-infected patients

作　　者：李维云[1] 侯向明[1] 李学斌[1] 孙晓慧[1] 焦振山[1] 乔树芳[1] 卢桂玲[1] 毛舒和[1] 

机构地区：[1]天津市长征医院皮肤科,天津300120

出　　处：《中国性科学》2008年第11期5-8,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨萆薢柴胡颗粒联合阿齐霉素与单纯阿齐霉素治疗NGU(MPC)的临床疗效及其调节免疫因子作用的研究。方法:将88例湿热血瘀型Ct感染患者随机分为中西医结合组和单纯西药组。在西药治疗的基础上,中西医结合组加服中药萆薢柴胡颗粒剂。采用酶联免疫吸附试验对两组的依从患者,进行治疗前后血清IFN-γ和IL-4分泌水平的检测。结果:中西医结合组的总有效率(90.7%)显著高于单纯西药组(73.3%)(P<0.01)。与对照组比较,治疗前两组患者血清IFN-γ分泌水平显著降低、IL-4分泌水平显著升高(P均<0.01);治疗后与治疗前比较,两组患者血清IFN-γ分泌水平升高、IL-4分泌水平降低,差别具有显著的统计学意义(P均<0.01);除单纯西药组IFN-γ外,其余各指标治疗后与对照组比较均无统计学意义。结论:萆薢柴胡颗粒联合阿齐霉素使用,可以显著提高临床对Ct感染所致NGU和MPC的疗效,并可有效调节Ct感染患者Th1/Th2平衡。Objectives ： To explore the curative efficiency of Chinese medical herbs, Bi - xie Chai - hu granule, combined with Azithromycin or Azithromycin alone in patients with nongonocoeal urethritis （ NGU ） and mucopurulent cervicitis （ MPC ） caused by Chlamydiatrachomatis （Ct） , and to compare their modulated effect on the balance of Th1/Th2. Methods： 88 Ct -infected patients with NGU and MPC, while companied with symptoms of damp - heat ＆ blood stagnancy, were randomly divided into two groups, the integrated treatment group ： patients took Chinese medicine of Bi - xie Chai - hu granule combined Azithromycin ; the antibiotic alone group ： only took Azithromycin. The serum contents of IFN - γ and IL - 4 were detected with ELISA method in the compliant patients before and at the end of the study. Results： The total efficiency rate in the integrated treatment group （90. 7% ） was significantly higher than that in antibiotic alone group （73.3%）, 〈0.01. Compared with normal control at the beginning of the trial, the serum of IFN - γ was lower and IL - 4 was higher significantly in both treatment groups. After one period of treatment, the contents of IFN - γ increased and IL - 4 decreased markedly than those at the beginning of the study, and besides the content of IFN - γ in antibiotic alone group, all profiles were no difference with the normal control at the end of the sutdy. Conclusion： The Bi - xie Chai - hu granule integrated with Azithromycin greatly promoted the curative efficiency in Ct -infected patients, and it had good effect on the balance of Th1/Th2.

关 键 词：中药治疗 非淋菌性尿道炎 免疫调控 

分 类 号：R277.721[医药卫生—中医学] R714.21