血清脱氢表雄酮水平与男性冠心病冠状动脉病变程度相关性分析  

Association of serum dehydroepiandrosterone levels with severity of coronary artery lesions in male patients

作　　者：沈忠海[1] 单友娟 马红松[1] 杨晓岚[1] 潘辉[1] 朱素娟[1] 

机构地区：[1]浙江省舟山市妇幼保健院,浙江舟山316000

出　　处：《中国卫生检验杂志》2008年第11期2430-2433,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的：观察血清脱氢表雄酮（DHEA）水平与男性冠心病冠状动脉病变程度的关系。方法：采用酶联免疫吸附试验检测血清脱氢表雄酮。并检测空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿酸等生化指标。结果：冠心病患者组血清脱氢表雄酮水平显著低于无冠心病组，P〈0．001。多元logistic回归分析显示，血清脱氢表雄酮为冠心病独立危险因素（OR=0．526；95％CI：0．361～0．768；P=0．001），血清脱氢表雄酮水平与冠心病冠状动脉狭窄程度呈负相关（t=3．424，P=0．001，r=-0．415）。控制其他冠心病危险因素后，血清脱氢表雄酮仍然与冠心病冠状动脉病变程度呈负相关（t=3．424，P=0．001，r=-0．415）。结论：血清DHEA水平的降低可能是导致男性冠心病发病率升高的重要因素，监测血清DHEA水平有助于判断冠心病病变的程度。Objective： To observe the role of serum concentration of dehydroepiandro - sterone （DHEA） in male patients with coronary atherosclerosis. Methods： Serum concentration of DHEA was measured by ELISA in 50 male patients with coronary atherosclerosis and 50 male controls without coronary abnormality. Results：Male patients with coronary heart disease （CHD） had significantly lower levels of DHEA compared with controls,P 〈 0. 001. In multiple logistic regression analysis, DHEA levels were associated with CHD independent of age ,TG,TC ,HDL - C ,LDL - C ,BG and URIC（ OR =0. 526;95% CI：0. 361 -0. 768 ;P =0. 001 ）. DHEA levels correlated Negatively with CHD lesion severity in male patients（ t = 3. 424, P = 0. 001, r = -0. 415 ）. The correlation remained significant even after controlling for age, TG, TC, HDL - C, LDL - C, BG and URIC （ t = 3. 424, P = 0. 001, r = - 0. 415）. Conclusion：Decrease in DHEA concentration in serum may play an important role in the cause of male coronary heart disease, and observation of DHEA concentration in serum may help to estimate the degree of coronary artery disease.

关 键 词：脱氢表雄酮 冠心病 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]