血管迷走性晕厥儿童24h尿电解质含量变化  

Changes of 24-hour urinary electrolytes contents in the children with vasovagal syncope

作　　者：王成[1] 刘晓燕[1] 郑慧芬[1,2] 李雯[1] 薛小红[1] 丁异熠[1,3] 胡春艳[1] Praveen Kumar 吴礼嘉[1] 

机构地区：[1]中南大学湘雅二医院儿科心血管病研究室中南大学儿科学研究所,长沙410011 [2]深圳市人民医院 [3]湖南省常德第一人民医院

出　　处：《中国急救医学》2008年第11期978-981,共4页Chinese Journal of Critical Care Medicine

基　　金：湖南省科技厅资助项目(No.06SK3036;No.2008SK3111);“十五”国家科技攻关计划项目(No.2004BA720A10);湖南省研究生创新基金项目(No.2340-74335000016)

摘　　要：目的探讨血管迷走性晕厥儿童24h尿电解质含量变化,对临床补盐补液治疗提供依据。方法2004-06～2007-04在中南大学湘雅二医院晕厥专科门诊就诊或住院的不明原因晕厥或先兆晕厥儿童79例(晕厥组),男31例,女48例,平均年龄(11.18±2.47)岁。匹配健康儿童11例为对照(对照组)。研究对象留取24h尿,测量尿量后,采用日本HITACHI公司7600-020全自动生化分析仪检测24h尿电解质(钾、钠、氯、钙、磷、镁)含量。结果①晕厥组24h尿量较对照组减少(P>0.05),24h尿电解质含量变化不明显(P>0.05),每毫升尿钠和尿钙增加(P<0.01或P<0.05)。②晕厥儿童HUTT阳性组24h尿钠、尿钾较HUTT阴性组明显增加(P<0.05),每毫升尿钠增加(P<0.05)。③晕厥儿童24h尿电解质含量和每毫升尿电解质含量在血管抑制型与心脏抑制型+混合型组、男女性别、<12岁组与≥12岁组、晕厥频次<4次组和晕厥频次≥4次组之间比较差异无统计学意义(P>0.05)。结论24h尿钠含量增加与VVS发病关系密切,临床治疗VVS要强调健康教育,重视补盐补液方案。Objective To explore the changes of 24 -hour urinary electrolytes contents in the children with vasovagal syncope （VVS） in order to provide the evidence for fluid and salt replacement in the clinical management of VVS. Methods There were 79 children, 31 males, 48 females, mean （ 11.18 ± 2.47 ） years old with unexplained syncope （UPS） or presyncope who came from syncope department or were hospitalized in the Second Xiangya Hospital of Central South University, and 11 healthy children were matched as control group. 24 - hour urinary samples were collected and measured, and urinary electrolytes contents （potassium, sodium, chlorine, calcium, phosphorus and magnesium） were detected by 7600 - 020 Automatic Biochemistry Analyzer from Japanese HITACHI Company. Statistical analysis was carried out among different groups. Results ①Compared with control group, 24 -hour urinary volume showed a slightly decrease （ P 〉 0.05 ） and 24 - hour urinary electrolytes contents had no significant changes in syncope group （ P 〉 0. 05 ） ; Urinary sodium per millilitre and urinary calcium per millilitre were significantly higher in syncope group than in control group （ P 〈 0.01, P 〈 0.05 ）. ②Compared with HUTT - negative group among VVS children, both 24 - hour urinary sodium and urinary potassium were significantly higher in HUTT - positive group （ P 〈 0.05 ） , urinary sodium per millilitre rose in HUTT - positive group （ P 〈 0.05 ）. ②There were no statistical differences in 24 - hour urinary electrolytes contents and urinary electrolytes contents per millilitre of VVS children between the vasodepressor type and the cardioinhibitory ＋ mixed types, male and female, age groups （ 〈 12 yrs and ≥12 yrs）. and syncope frequency groups （ 〈4 times and ≥4 times） （P 〉 0.05）. Conclusion There was a close relationship between 24 - hour urinary electrolytes contents and VVS. Health education and fluid and salt replacement should be emphasized in clinical treatment.

关 键 词：血管迷走性晕厥 儿童 24 h尿 电解质 

分 类 号：R720.597[医药卫生—急诊医学]