他汀类药物抗脓毒症作用研究进展  

Study of statins in anti-sepsis

作　　者：詹剑勇[1] 霍正禄[1] 

机构地区：[1]解放军第二军医大学附属长海医院急诊科,上海200433

出　　处：《中国急救医学》2008年第11期1030-1032,共3页Chinese Journal of Critical Care Medicine

摘　　要：脓毒症的发病率正日益增加,目前仍是临床危重症患者的主要死因。越来越多的临床观察研究和基础研究表明,他汀类药物有可能降低脓毒症患者的病死率,其作用机制包括抗炎、抗氧化、免疫调节、改善内皮功能、降低血液的凝血活性及增加NO的生物利用度等。然而,他汀类药物能否广泛应用于脓毒症治疗仍有待于在将来的临床试验中得到进一步验证。The incidence of sepsis is increasing and remains the leading cause of death in critically ill patients. Evidences emerge from observational studies and basic science research that statins might be associated with reduced mortality in sepsis. Its potential mechanisms include antiinflammation and antioxidation, immunoregulation, improvement in endothelial function, reduction in blood thrombogenicity and increased nitric oxide （NO） bioavailability. However, the available evidence today suggests that the potential for statins as adjuvant therapy for sepsis should he further tested.

关 键 词：他汀类药物 HMG—CoA还原酶抑制剂 脓毒症 

分 类 号：R459.7[医药卫生—急诊医学]