高乌甲素对混合痔手术患者IgA、IgM、IgG水平的影响  

Lappaconitine Effect on IgA, IgM and IgG Levels of the Patients with Mixed Hemorrhoids

作　　者：魏涛[1] 

机构地区：[1]山东中医药大学附属医院,山东济南250011

出　　处：《中国肛肠病杂志》2008年第11期14-15,共2页Chinese Journal of Coloproctology

摘　　要：为探讨高乌甲素（lappaconitine，LA）对痔手术患者IgA、IgM、IgG水平的影响，选择行混合痔外剥内扎术患者36例，随机分为3组，高乌甲素组（L组）、曲马多组（T组）、空白对照组（B组），每组12例。L组、T组术前30min分别静脉滴注LA8mg、曲多马100mg，30min滴注完毕。麻醉后即开始在L组、T组连接电子输注泵，以LA0．28mg／ml或曲马多8mg／ml进行持续背景输注，术后再实施PCA。分别于麻醉用药前30min、术毕即刻、术后24h、术后48h取外周静脉血，测定IgA、IgM、IgG。结果B组术后48h血清IgA降低，与L组比较有显著性差异（P〈0．05）；B组、T组术后24h血清IgM降低，与L组比较有显著性差异（P〈0．05）；B组术毕即刻、术后24h血清IgG降低，与L组比较有显著性差异（P〈0．05）。结果表明，LA于痔术后在一定程度上可稳定血清IgA、IgM、IgG水平。The objective of this study was to detect lappaconitine（LA） effect on the levels of IgA,IgM,IgG in hemorrhoidal patients. The 36 patients with mixed hemorrhoids were randomized in to 3 groups, 12 in each group（LA group, the tramadol group and the placebo group）. Patients in LA group and tramadol group received intravenous drop of LA 8mg and tramadol 100mg in 30 min,then received background pump supply of LA 0.28mg/ml or tramadol 8mg/ml,and PCA was conducted postoperatively. Peripheral venous blood was taken（30 min before anesthesia,immdiately after the hemorrhoid operation and at postoperative 24th ＆ 48th h） for IgA, IgM and IgG examination. As results, IgA level in the placebo group was much lower at postoperative 48th h against that in the LA group（ P 〈0.05） ;IgM level was much lower in placebo group and tramadol group at 24th h against that in LA group（ P 〈0.05） ;and the IgG level immediately after operation and at the postoperative 24th h in placebo group was much lower against that in LA group （P 〈0.05）. It is concluded that lappaconitine can stabilise IgA,IgM and IgG levels when applied after hemorrhoid operation.

关 键 词：痔 手术 高乌甲素 IGA IGM IGG水平 

分 类 号：R711.6[医药卫生—妇产科学] R532.21[医药卫生—临床医学]