有发热史人员的疟疾血清流行病学调查  

Seroepidemiological survey of malaria among people with fever history

作　　者：刘慧[1] 魏春[1] 许建卫[1] 陶红 黄国珍[1] 刀颖 

机构地区：[1]云南省寄生虫病防治所,云南普洱665000 [2]西盟县疾病预防控制中心 [3]西盟县岳宋乡卫生院

出　　处：《中国病原生物学杂志》2008年第11期847-848,857,共3页Journal of Pathogen Biology

基　　金：WHO/ADB加强少数民族疟疾防治试点研究项目(No.WPMVP/2005/ICP/MAL/1.2/001)。

摘　　要：目的探讨有发热史人员的间接荧光抗体试验（IFAT）在疟疾流行病学调查中的应用价值。方法对上年有发热史者采血,进行疟疾间接荧光抗体检测。结果IFAT总体阳性率为71.6%（95%CI66.6%-76.2%）,高滴度者（≥1∶80）占阳性数的30.57%（95%CI24.83%-36.81%）;抗体阳性率、滴度分布和logistic回归分析结果均显示≥15岁人群疟疾流行程度显著高于〈15岁人群,但性别间差异无统计学意义。结论以发热史人员作为检测对象,可以提高IFA试验的使用效率。Objective To explore the potential value of indirect immunofluorescent antibody test （IFAT） in the epidemiology of malaria among these people with fever history. Methods IFAT were carried out for serological samples collected from people with fever episodes within one year before the investigation. Results The total positive rate of IFAT was 71.6% （95%CI66.6%-76.2%）, and the proportion of high titers （≥1： 80） was 30.57% （95%CI 24.83%- 36.81 % ） of total positive samples. All evidences of IFAT positivity rate, titer distribution and logistic regression showed that malaria prevalence of ≥15 year age group was significantly higher than the 〈15 year age group, however no evidences showed any difference between of male and female groups. Conclusion Taking people with fever history as subjects can improve the efficiency of IFAT.

关 键 词：疟疾 间接荧光抗体试验 无条件logistic回归 

分 类 号：R531.3[医药卫生—内科学]