2型糖尿病肾病与PPAR-γ2 Pro12Ala单核苷酸多态性的相关性研究  

The relationship between the pro12Ala polymorphism in PPAR-γ2 gene and diabetic nephropathy in Baotou

作　　者：魏枫[1] 王津京[1] 王彩丽[2] 霍晓静[1] 薛晔霞[1] 白琳院 

机构地区：[1]内蒙古科技大学包头医学院第一附属医院内分泌科,014010 [2]内蒙古科技大学包头医学院第一附属医院肾内科,014010

出　　处：《中国糖尿病杂志》2008年第11期679-680,共2页Chinese Journal of Diabetes

基　　金：包头医药卫生基金(2005G30020-21)

摘　　要：PPAR-γ2Pro12Ala(P12A)单核苷酸多态性(SNP),包括PP、PA、AA三种基因型,由于AA突变率很低,用XA作为PA、AA共同代称。受试者301例,用RFLP-PCR行基因型测定。单纯T2DM组XA基因型频率明显低于正常对照组(0.101vs0.283,P<0.05);糖尿病肾病(DN)组及肌酐清除率减低(DN2)组中XA基因型者UAlb/Cr有明显降低(P<0.05)。XA基因型携带者T2DM发病率降低,与DN发病无关。301 subjects were selected. The pro12Ala polymorphism of PPAR-γ2 gene was screened by polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） in 301 subjects. The frequency of the Pro12Ala mutation was significantly lower in T2DM than in control group（0. 101 vs 0. 283,P〈 0.05）. The genotype of XA may be independent proctective factor for the pathogenesis of T2DM, but showed no relationship with DN （OR=0. 284,95% CI=0. 132-0. 611）.

关 键 词：多态性 单核苷酸 过氧化物酶体增殖物受体γ2 基因型 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]