β-四(对羟甲基苯氧基)酞菁锌的合成及其抗肿瘤活性  

Synthesis of β-Tetra-[(p-hydroxy methyl)phenoxy] Phthalocyanine Zinc and Its Antineoplastic Activity

作　　者：李晓丽[1] 陈伟[1] 王玉[2] 李涛[2] 夏春辉[2] 邸凯[1] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院,黑龙江齐齐哈尔161042

出　　处：《合成化学》2008年第6期640-643,共4页Chinese Journal of Synthetic Chemistry

基　　金：黑龙江省教育厅科学技术研究资助项目(11511441);黑龙江省卫生厅科学技术研究资助项目(2005-333);黑龙江省齐齐哈尔市重点科技资助项目(GY05-19SFG06-02)

摘　　要：以4-硝基邻苯二腈和对羟基苯甲醇为原料,经两步法设计并合成了两亲性β-四(对羟甲基苯氧基)酞菁锌(Ⅱ)光敏剂(1),其结构经UV-vis,1H NMR,IR,激光解吸电离飞行时间质谱(TOF-MS)及元素分析表征。用HE染料法和MTT染色法研究了1对Bel-7402人体肝癌细胞的抑制作用,考察了c(1)对Bel-7402细胞抑制率的影响。实验结果表明,当c(1)为50 mg.L-1时,抑制率达67%,其IC50=30.1 mg.L-1。Photosensitizer, β-tetra-[ （p-hydroxy methyl）phenoxy] phthalocyanine zinc（ Ⅱ ） （1）, was designed and synthesized by a two-step reaction from 4-nitro-phthalonitrile and p-hydroxy-benzoic alcohol. The inhibiting effect of 1 on human Bel-7402 liver cancer cells was investigated by HE dye method and MTT colorimetric assay. The effect of cell inhibition ratio of c（1 ） on Bel-7402 was systematically studied. The results showed that the cell inhibition ratio on Bel-7402 can reach 67% and its IC50 numerical value was 30.1 mg·L^-1 under the condition of c（1） being 50 mg ·L^-1.

关 键 词：酞菁锌 光敏剂 BEL-7402细胞 合成 抗肿瘤活性 

分 类 号：O644.12[理学—物理化学] R735.7[理学—化学]