香烟烟雾水溶物对小鼠急慢性毒性实验的研究  

The Acute and Chronic Toxicity of Water-soluble Contents of Cigarette Smoke in Mice

作　　者：顾小红[1] 周颖婷[1] 张淑华[1] 睢凤英[1] 

机构地区：[1]嘉兴学院医学院,浙江嘉兴314001

出　　处：《嘉兴学院学报》2008年第6期29-31,共3页Journal of Jiaxing University

摘　　要：通过以制备香烟烟雾水溶液(water-soluble contents of cigarette smoke,WSCCS)为阳性对照组,生理盐水为阴性对照组,观察0.1ml/10g、0.2ml/10g、0.4ml/10g的WSCCS对小鼠的急慢性(稀释原配制溶液50倍)毒性作用.结果显示:急性中毒小鼠可出现耳部黏膜变白,竖尾,呼吸、心率加快,抽搐,惊厥甚至死亡;慢性中毒小鼠则出现体重下降、性格暴躁、大便溏稀等症状,解剖后可观察到内脏各器官肺、肝、肾、胃肠道颜色、体积等改变.由此得出香烟烟雾水溶物对小鼠各系统有较强的急性和慢性毒性作用,从而间接证明香烟对人体会产生各种可能的危害.The water - soluble substances of cigarettes smoke is used as positive control and the normal saline as blank control to give injection to mice. Observation are made of the acute and chronic toxicity of WSCCS toward small mice at the levels of 0.1 ml/10g,0.2ml/10g,0.4ml/10g. Results show that the acute poisoning symptoms in mice are vertical tail, white ears, increase of breath and heart rate, twitch, convulsion and even death; while the chronic poi- soning symptoms in mice are observed as the changes of color and volume in lung, liver, kidney, and gastrointestinal tract. The conclusion could be reached as that the water - soluble contents of cigarette smoke have more acute and chronic toxicity, which could indirectly indicate the various possible hazards brought by cigarette to human body.

关 键 词：香烟烟雾水溶物 急性毒性 慢性毒性 

分 类 号：R163[医药卫生—公共卫生与预防医学]