双氯芬酸钠胶浆剂家兔直肠给药的药动学特征  

Pharmacokinetic characteristic of diclofenac sodium mucilage in rabbits after a single dose of rectal administration

作　　者：刘加升[1] 夏安周[2] 邢淑华[2] 秦伟[2] 吴晓丽[2] 卓九五[2] 张莉[2] 

机构地区：[1]江苏沛县中医院外科,徐州221600 [2]徐州医学院药理学教研室,徐州221004

出　　处：《中国临床药学杂志》2008年第6期345-348,共4页Chinese Journal of Clinical Pharmacy

基　　金：徐州市科学技术基金资助(X2005F417)

摘　　要：目的研究双氯芬酸钠胶浆剂直肠给药在家兔体内的药动学。方法24只家兔随机分为2组,每组12只(♀♂各半),分别直肠给予双氯芬酸钠胶浆剂和栓剂(3mg·kg-1),按试验方案采血,采用HPLC法测定血药浓度。结果双氯芬酸钠胶浆剂组tmax为12.60min,ρmax为8.39mg·mL-1(P<0.001);双氯芬酸钠栓剂组tmax为94.46min,ρmax为5.62mg·mL-1(P<0.001)。结论双氯芬酸钠胶浆剂直肠给药后血药峰浓度高,且达峰时间短,优于双氯芬酸钠栓剂直肠给药。AIM To study the pharmacokinetics of diclofenac sodium mucilage in rabbits. METHODS Twentyfour rabbits （12 male and 12 female） were randomly divided into two groups. Twelve rabbits in diclofenac sodium mucilage group（3 mg· kg^-1） were given with rectal administration and 12 rabbits in diclofenac sodium suppository group（3 mg· kg^-1） were given with rectal administration. Blood samples were collected according to the test program and the serum concentrations of diclofenac sodium were measured. RESULTS The values of t were 12.60 rain and 94.46 rain （ P 〈 0. 001 ）, Pmax, were 8.39 mg· L^- 1 and 5.62 mg· L^- 1 （ p 〈 0. 001 ）, with diclofenac sodium mucilage group and dielofenae sodium suppository group. CONCLUSION The Pmax is high and tmax is quick of dielofenae sodium mucilage than that of diclofenac sodium suppository, with ractal administration.

关 键 词：双氯芬酸钠胶浆 药动学 直肠给药 

分 类 号：R96[医药卫生—药理学]