树突状细胞的免疫耐受性及其在抗移植排斥中的应用  

Immune tolerance of dendritic cells and its role in graft rejection

作　　者：邹绍武[1] 傅志仁[1] 王全兴[2] 

机构地区：[1]第二军医大学长征医院器官移植中心,上海200003 [2]第二军医大学基础部免疫学教研室,上海200433

出　　处：《第二军医大学学报》2008年第11期1386-1389,共4页Academic Journal of Second Military Medical University

摘　　要：树突状细胞(dendritic cell,DC)作为专职抗原递呈细胞,其强大的抗原递呈以及免疫调节能力越来越引起人们的重视。近年来认为,DC具有调控免疫应答的作用,不仅可激发免疫反应,也可介导免疫耐受。DC的这种异质性决定了DC在肿瘤、自身免疫性疾病及移植排斥的免疫反应中起着重要的作用。As an antigen-presenting cell, dendritic cells （DCs）have drawn great attention due to its powerful antigen-presenting ability and immunological regulation function. Recently, it is believed that I）Cs also participate in regulation of immune response： DCs can not only stimulate immune response, but also induce immune tolerance. This heterogeneity of DCs determines that they play very important role in the immune response in tumors, autoimmunity diseases and graft rejections.

关 键 词：树突细胞 移植物排斥 免疫耐受 

分 类 号：R392.4[医药卫生—免疫学]