致病真菌凋亡机制的研究进展  

Apoptotic mechanism of Pathogenic fungi:recent progress

作　　者：戴宝娣[1] 曹颖瑛[2] 徐勇刚[2] 高平挥[2] 王彦[2] 姜远英[2,1] 

机构地区：[1]沈阳药科大学药理学教研室,沈阳110016 [2]第二军医大学药学院药理学教研室,上海200433

出　　处：《第二军医大学学报》2008年第11期1390-1394,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30630071,30870105)~~

摘　　要：随着耐药致病真菌的临床检出率不断攀升,其死亡机制的探讨也成为了热点。致病真菌的凋亡是由许多信号通路、调节因子和效应物质组成的复杂网络。致病真菌的凋亡与真菌的自体吞噬、线粒体凋亡通路、内源性和外源性因素的变化等密切相关。凋亡通路作为抗真菌药物研究的新靶点,其临床意义十分重大。因此,本文对致病真菌凋亡通路做一综述。Apoptotic mechanism of Pathogenic fungi has become a focus of study due to the worsening situation of clinical drug resistance in fungi. Apoptosis of Pathogenic fungi is a complicated network involving many pathways, regulators and effectors. Besides, it is closely related to the autophagy, mitochondrial apoptotic pathways, and changes of endogenous and exogenous factors. As a new target of antifungal agent, apoptotic pathways are of great chnical importance. This paper reviews the apoptotic pathways of Pathogenic fungi.

关 键 词：致病真菌 细胞凋亡 信号通路 

分 类 号：R379[医药卫生—病原生物学]