磁共振扩散成像在慢性肾病中的初步研究  

Primary Study of Chronic Kidney Disease with MR Diffusion-Weighted Imaging

作　　者：李晨霞[1] 孙兴旺[1] 张月浪[1] 

机构地区：[1]西安交通大学医学院第一附属医院影像中心,陕西西安710061

出　　处：《实用放射学杂志》2008年第11期1507-1511,共5页Journal of Practical Radiology

摘　　要：目的探讨磁共振扩散加权成像在慢性肾病中的应用价值。方法将10例健康志愿者和45例不同分期的慢性肾病患者(包括慢性肾病肌酐正常者10例,慢性肾衰肾功能代偿者9例,慢性肾衰肾功能失代偿者9例,慢性肾功能衰竭者8例及慢性肾衰尿毒症者9例)进行常规肾脏磁共振检查和扩散加权成像检查。观察分析其扩散成像的影像学表现,使用系统软件包在ADC图上直接测量肾脏的ADC值。结果慢性肾病肾脏的ADC值(×10-3mm2/s)在b值为300、500、800s/mm2时分别为2.29±0.27、2.07±0.21、1.91±0.22,均明显低于正常对照组肾脏ADC值;慢性肾病不同分期患者肾脏ADC值之间可能有差异。结论DWI可以作为临床评价肾脏功能的一种无创检查手段。Objective To study the applied value of MR diffusion - weighted imaging （DWI） and apparent diffusion coefficient （ADC） value in chronic kidney disease （CKD）. Methods 10 healthy volunteers and 45 patients with different period of CKD underwent routine MRI and DWI. The DWI features were observed. The ADC values were acquired by using Philips soft package on the ADC images. Results Under different b value（ 300 s/mm^2 , 500 s/mm^2 and 800 s/mm^2 ） , the ADC value of CKD were 2.29 ± 0.27,2.07 ± 0.21 and 1.91 ± 0.22 , respectively,which were significantly lower than that in norman kidneys,and there was statistical difference between different group of CKD. Conclusion DWI may be a noninvasive method to evaluate the renal function.

关 键 词：肾脏 扩散加权成像 慢性肾病 磁共振成像 

分 类 号：R692[医药卫生—泌尿科学] R445.2[医药卫生—外科学]