手性铝化合物催化不对称氢转移反应的研究  

Asymmetric transfer hydrogenation of aryl ketone catalyzed by Al catalysts

作　　者：田欣哲[1] 任运来[1] 张燕[1] 何社彬[1] 孙鲲鹏[2] 

机构地区：[1]河南科技大学化工与制药学院,河南洛阳471003 [2]中科院兰州化学物理研究所羰基合成与选择氧化国家重点实验室,甘肃兰州730000

出　　处：《工业催化》2008年第11期64-67,共4页Industrial Catalysis

摘　　要：以手性铝化合物为催化剂,异丙醇为氢源,进行芳香酮的不对称氢转移反应。在考察的酮类底物中,大部分具有较高收率,产物光学收率ee最高为83%。当配体和催化剂物质的量比为1时,反应效果最好。又考察一些手性二醇配体,其中,茚衍生的配体有着较好的手性诱导性能。Asymmetric transfer hydrogenation of aryl ketones was studied using chiral aluminum compounds as catalysts and isopropanol as hydrogen source. For majority of the ketone products, higher yield was obtained with up to 83% ee. Optimal results were obtained under ligand-to-catalyst molar ratio of 1： 1. Some ehiral diols were also investigated as the ligands, with those derived from indene exhibiting better enantioselectivity.

关 键 词：催化化学 不对称氢转移 铝化合物催化剂 手性二醇 

分 类 号：TQ426.94[化学工程] O643.32[理学—物理化学]