呼吸科病房铜绿假单胞菌耐药性分析  

Analysis on Resistance of Pseudomonas Aeruginosa and Antibiotic Applicationof Respiratory Ward

作　　者：陈海滨[1] 周光[1] 

机构地区：[1]中国人民解放军总医院,北京100853

出　　处：《中国药业》2008年第23期47-48,共2页China Pharmaceuticals

摘　　要：目的促进临床合理选择抗菌药物。方法采用回顾性调查方法,对该院呼吸科病房2004年1月至2006年12月铜绿假单胞菌的药物敏感试验结果与常用抗菌药物的年消耗量进行统计分析。结果3年间,该院呼吸科从临床标本中共分离细菌1048株,其中铜绿假单胞菌208株,分离率最高(19.85%);铜绿假单胞菌对左氧氟沙星、头孢哌酮舒巴坦钠、亚胺培南等的耐药性3年间均有不同程度地增加,头孢他啶、阿米卡星对铜绿假单胞菌仍有较好的抗菌活性,头孢吡肟保持着较高的敏感率。结论铜绿假单胞菌对消耗量大的抗菌药物耐药率高且多重耐药菌较普遍。根据药物敏感试验结果合理使用抗菌药物,对减缓细菌耐药性的增长非常重要。Objective To analyze the resistance change of Pseudomonas aeruginosa during three years in the respiratory ward of our hospital for promoting the rational selection and application of antibiotics. Methods The drug sensitivity tests results of Pseudomonas aeruginosa and the amount of antibiotic consumption between January 2004 and December 2006 in the respiratory ward were analyzed with the retro- spoctive survey method. Results Total 1 048 clinical isolates were isolated from 2004 to 2006. 208 Pseudomonas acruginosa isolates were among them, accounting for 19. 85%. The resistance rate of Pseudomonas aeruginosa to levofloxacin, cefoperazone/sulbactam sodium and imipenem increased. Ceftazidine and amikacin still showed a good antibacterial activity against Pseudomonas aeruginosa. Cefepime also main- tained a highly sensitive rate against Pseudomonas aeruginosa. Conclusion Pseudomonas aeruginosa is resistant to many commonly used antibiotics and multiple drug resistance is more common. It is important for us to control antibiotic resistance by using antibiotics reasonably.

关 键 词：铜绿假单胞菌 抗菌药物 耐药性 

分 类 号：R969.3[医药卫生—药理学] R915[医药卫生—药学]