^131I治疗Graves病伴白细胞减少的临床研究  

Clinical study on ^131I therapy Graves disease complicated with peripheral blood leukcytopenia

作　　者：张志祥[1] 郑岚[1] 罗加[1] 郑世霞[2] 吴红[2] 

机构地区：[1]重庆市第三人民医院核医学科,400014 [2]重庆市第三人民医院内科

出　　处：《国际放射医学核医学杂志》2008年第4期229-231,共3页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的探讨^131I治疗Graves病（GD）伴外周血白细胞减少的疗效。方法对GD伴外周血白细胞减少患者^131I治疗前后测定白细胞计数和甲状腺激素（三碘甲腺原氨酸、甲状腺素、促甲状腺激素）水平，并进行比较。结果^131I治疗GD伴白细胞减少疗效显著，甲亢治愈率100％；^131I治疗GD前后外周血白细胞计数没有明显变化，治疗后3个月血清甲状腺激素水平明显下降。结论^131I治疗GD伴白细胞减少可行且疗效显著，治疗剂量的^131I辐射对外周血白细胞水平没有影响。Objective To investigate the effect of ^131I therapy Graves disease （GD） Complicated with peripheral blood leukopenia in hyperthyroid patients. Methods Serum T3, T4, TSH levels and peripheral blood white blood cell counts were determined in 16 GD complicated with leukopenia patients both before and after ^131I therapy. Results ^131I treatment of GD complicated with leukopenia patients was very successful （P〈0.01）, the cured rate was 100%. The peripheral blood white blood cell counts were few changes in GD patients both before and after ^131I T3, T4, TSH levels was decreased within three months after ^131I therapy. Conclusion The application of ^131I to treat GD complicated with leukopenia was very successful. The therapeutic dose of ^131I was no remarkable effect on peripheral blood white blood cell.

关 键 词：碘放射性同位素 放射疗法 格雷夫斯病 白细胞减少 甲状腺激素类 

分 类 号：R581.1[医药卫生—内分泌] R557.1[医药卫生—内科学]