头孢地秦对慢性阻塞性肺疾病急性加重期的疗效观察  

Clinical Observation of Cefodizime on Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：王卫东 张向丽 王建业 许豪 

机构地区：[1]河南省平舆县中医院,463400 [2]平舆县疾病预防控制中心

出　　处：《职业与健康》2008年第23期2612-2613,共2页Occupation and Health

摘　　要：目的评价头孢地秦（CDZ）对慢性阻塞性肺疾病急性加重期（AECOPD）的临床疗效。方法采用临床病例对照观察方法把112例AECOPD患者随机分为观察组（43例）和对照组（69例）。观察组抗生素首选CDZ 50mg／kg，q12h；对照组选用其他β内酰胺类药物。选用复方抗生素者为对照Ⅰ组（33例），选用单一抗生素者为对照Ⅱ组（36例）。统计分析首选抗生素5d内换药率及各组间预后的差异。结果112例患者首选抗生素共6种，5d换药率观察组为11．6％，其他5种抗生素为36．4％～66．1％，首选抗生素的换药率和最终治疗的有效率呈负相关（r=0．888，P〈0．05）。观察和对照Ⅰ、Ⅱ组有效率分别为93．0％、72．7％和66．7％，差异有统计学意义（均P〈0．01）。结论观察组临床疗效较好，可作为治疗AECOPD的新选择。[ Objective] To evaluate the clinical effects of cefodizime{ CDZ） on the patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. [ Methods] Clinical cases control observation method was applied to divide 112 cases of AECOPD into observation group （43 cases） and control group （69 cases）. The control group received CDZ 50 mg/kg,q 12 h;The control group received other β-laetam antibiotics. Compound antibiotics were given to the control group Ⅰ （ 33 cases） , and simple antibiotics were for the control group Ⅱ （ 36 cases）. The 5-day preferred antibiotic dressing change and the group prognosis differences were statistical analyzed. [Results] There were 6 antibiotics as the first choice in the 112 cases. The changing rate in 5 days was 11.6% for observation group and the other 5 antibiotics were 36.4% -66.1%. The prognosis of AECOPD had negative correlation with the antibiotics changing rate （ r = - 0. 888,P 〈 0.05 ）. Effective rates of observation group, control Ⅰ and control Ⅱ groups were 93.0% ,72.7% and 66.7% respectively, the difference was significant（ P 〈 0.01 ）. [ Conclusion ] The observation group has good clinical effect, CDZ can be used as a new antibacterial choice for AECOPD.

关 键 词：慢性阻塞性肺疾病 急性加重期 头孢地秦 预后 

分 类 号：R563[医药卫生—呼吸系统]