颈动脉斑块内新生血管与血浆髓过氧化物酶浓度及脑梗死的相关性研究  

Study on the relationship between the neovascularization of carotid atherosclerotic plaques, plasma myeloperoxidase （MPO） concentration and cerebral infarction

作　　者：朱文晖[1] 李瑞珍[1] 唐水娟[1] 周平[1] 何炜[1] 肖际东[1] 

机构地区：[1]中南大学湘雅三医院超声科,长沙410013

出　　处：《中华超声影像学杂志》2008年第11期952-955,共4页Chinese Journal of Ultrasonography

基　　金：湖南省自然科学基金项目（03JJY4043）

摘　　要：目的探讨颈动脉粥样斑块内新生血管的实时超声造影显像特征与血浆髓过氧化物酶（MPO）浓度及脑梗死事件的关系。方法对73例颈动脉粥样硬化患者的89处斑块行超声造影（CEUS），根据斑块的回声特征，将其分为软斑组、混合斑组及硬斑组，比较三组间的脑梗死率、MPO浓度及斑块内造影剂增强持续时间的差异，并分析造影剂增强持续时间与血浆MPO浓度的相关性。常规对患者行头部CT或MRI检查，确诊脑梗死事件。结果软斑组脑梗死率、MPO浓度及斑块内造影剂增强持续时间显著高于混合斑组及硬斑组，差异有统计学意义（P〈0．01），脑梗死组MPO浓度显著高于非脑梗死组，差异有统计学意义（P〈0．01），斑块内造影剂增强持续时间与血浆MPO浓度呈高度正相关，相关系数为0．838。结论斑块的类型与斑块内新生血管的形成及血浆MPO浓度有关，对其关系的研究有助于全面评价斑块的稳定性，并指导临床预防脑梗死事件的发生。Objective To study the relationship between the neovascularization of carotid atherosclerotic plaques with real time contrast-enhanced ultrasonography（CEUS）, plasma myeloperoxidase （MPO） concentration and cerebral infarction. Methods Seventy-three cases with eightynine carotid atherosclerotic plaques were examined with real-time CEUS. According to the imaging features,the seventythree cases were divided into three groups：soft plaques group, hard plaques group and mixed plaques group. The differences of the incidence rate of cerebral infarction events, plasma MPO concentration and contrast media persistent enhancement time with real time CEUS in plaques among the three groups were analyzed. The cerebral infarction events were diagnosed by CT or MRI routinely. Results The incidence rate of cerebral infarction events, plasma MPO concentration and contrast media persistent enhancement time of soft plaques group were significantly higher than that in hard plaques group and mixed plaques group. The risk of cerebral infarction was higher in the patients with elevated level of MPO. It showed positive correlation between the contrast media persistent enhancement time and plasma MPO concentration,and the correlation coefficient was 0. 838. Conclusions The type of the plaque is correlated with the neovascularization of plaques and plasma MPO concentration. The study of relationships among them can help to evaluate the plaques, stability thoroughly and guide the clinician to prevent the incidence of cerebral infarction events.

关 键 词：超声检查 微气泡 颈动脉狭窄 过氧化物酶 脑梗塞 

分 类 号：R686[医药卫生—骨科学]