不同类型卵巢过度刺激综合征对妊娠结局的影响  

Influence of Different Types of Ovarian Hyperstimulation Syndrome on Obstetric Outcome

作　　者：范燕宏[1] 乔杰[1] 陈贵安[1] 刘平[1] 马彩虹[1] 陈新娜[1] 王海燕[1] 

机构地区：[1]北京大学第三医院生殖中心,北京100083

出　　处：《生殖与避孕》2008年第11期690-694,698,共6页Reproduction and Contraception

摘　　要：目的:分析卵巢过度刺激综合征(OHSS)发病早晚、病情轻重、病程长短对妊娠结局的影响。方法:对于行IVF-ET而发生中、重度OHSS的132例患者(早发型83例,晚发型49例;中度34例,重度98例;短病程103例,长病程29例;妊娠72例)临床资料进行回顾性分析。结果:①OHSS患者妊娠丢失与双胎、OHSS发病早晚、病情轻重、病程长短无显著性相关(P>0.05),但在晚发型妊娠丢失比率高于早发型、重度比率高于中度、病程长者比率高于病程短者。②早产与双胎有显著性相关(P<0.01),与OHSS发病早晚、病情轻重、病程长短无显著性相关(P>0.05)。③低体重儿与双胎有显著性相关(P<0.01),与OHSS发病早晚、病情轻重、病程长短无显著性相关(P>0.05)。结论:OHSS患者的流产比率与发病早晚、病情轻重、病程长短也无显著性相关,但在发病晚、病情重、病程长者比率略高;低体重儿、早产与双胎有显著性相关,与发病早晚、病情轻重、病程长短无相关性。Objective： To analyze the influence of the presented time, the degree and the duration of OHSS on the obstetric outcome of pregnant patients. Methods： A total of 132 patients undergoing IVF （including the patients of the early occurrent type 83, the late occurrent type 49; the moderate type 34, the severe type 98; the shorter duration type 103; the longer duration type 29; 72 pregnant patients） who were hospitalized for moderate or severe OHSS were analyzed retrospectively. Results： 1） The loss of pregnancy with OHSS patients was not related to the fetal number, the time of disease presented, the degree of disease and the duration of disease （P〉0.05）. But it was higher in the late occurrent type, in the severe type, and in the longer duration type （more than 14 d） than that in the early occurrent type, in the moderate type and in the shorter duration type, respcetively. 2） Premature delivery was significantly related to the twins（P〈0.01）, but it was not significantly related to the time of disease presented, the degree of disease and the duration of disease （P〉0.05）. 3） Low birth weight was significantly related to the twins and premature delivery （P〈0.01）, but it was not significantly related to the time of disease presented, the degree of disease and the duration of disease （P〉0.05）. Conclusion： The pregnancy loss was not significantly related to the fetal number, the time of disease presented, the degree of disease and the duration of disease, but it was higher in the late occurrent type, in the severe type, and in the longer duration type. Low birth weight and premature delivery were significantly related to the twins, but not significantly related to the time of disease presented, the degree of disease and the duration of disease.

关 键 词：卵巢过度刺激综合征(OHSS) 妊娠 妊娠丢失 早产 低体重儿 

分 类 号：R711.75[医药卫生—妇产科学]