眶额叶微量注射谷氨酸和γ-氨基丁酸对胃运动的影响及其机制探讨  

EFFECT AND MECHNAISIM OF GLU AND GABA IN OFC ON GASTRIC MOTILITY

作　　者：乔卉[1] 廉婷[1] 宋绍丽[1] 安书成[1] 

机构地区：[1]陕西师范大学生命科学学院,陕西西安710062

出　　处：《中国应用生理学杂志》2008年第4期483-486,共4页Chinese Journal of Applied Physiology

基　　金：陕西省自然科学基金资助项目(2006C240)

摘　　要：目的:研究眶额叶(OFC)的谷氨酸(Glu)和γ-氨基丁酸(GABA)含量变化对胃运动的影响及其调节神经机制。方法:实验采用了大鼠眶额叶微量注射给药,结合核团损毁的方法,以记录胃内压,统计胃收缩幅度作为胃运动变化的指标。结果:①OFC注射Glu可显著降低胃收缩幅度,损毁杏仁核后可反转该效应,胃收缩幅度显著增强;损毁蓝斑核后,Glu的作用无显著性变化。②OFC注射GABA可显著增强胃的收缩幅度,损毁蓝斑核后消除该效应;损毁杏仁核后,胃收缩幅度进一步增强。结论:外源性增加OFC区Glu含量导致的抑胃效应可能是通过增强了杏仁核的经常性抑胃作用而引起的;而增加OFC区GABA的含量引起的胃运动增强与蓝斑核密切相关。Aim： To Investigate the effect of glutamate （Glu） and gamma-aminobutyric acid （GABA） in orbitofrontal cortex （OFC） on regulation of gastric motility. Methods： Using microinjection in OFC, together with lesion of related nucleus,and recording the intragastric pressure（IGP）. Results： OMicroinjection of Glu in OF（1） caused a significant reduce of the amplitude of gastric motility, this effect could be reverse by lesion of amygdala,while lesion of LC had no influence on the effect of Glu. （2）microinjection of GABA in OFC could increase the amplitude of gastric motility significantly, and lesion of LC could abolish this effect, while lesion of amygdala could enhance the effect of GABA more. Conclusion： Microinjection of Glu in OF（7 may enhance the normal inhibitory effect of amygdale on gastric motility, and the effect of microinjection of GABA in OFC on gastric motility is closely related with LC.

关 键 词：眶额叶 GABA GLU 胃运动 

分 类 号：Q42[生物学—神经生物学]