Molecular Modification of a HSV-1 Protein and Its Associated Gene Transcriptional Regulation  

作　　者：Yan-chun CHE Li JIANG Qi-han LI 

机构地区：[1]Institute of Medical Biology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, No. 379 Jiao Ling Road, Kunming 650118, China

出　　处：《Virologica Sinica》2008年第6期394-398,共5页中国病毒学（英文版）

基　　金：National Natural Science Foundation of China (30670094,30700028)

摘　　要：The molecular modifications of Herpes Simplex Virus Type I （HSV-1） proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/ assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulationThe molecular modifications of Herpes Simplex Virus Type Ⅰ (HSV-1) proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulation.

关 键 词：MODIFICATION Herpes simplex virus type （HSV- 1） Transcriptional regulation 

分 类 号：Q539[生物学—生物化学] Q782