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作 者:Yan-chun CHE Li JIANG Qi-han LI
出 处:《Virologica Sinica》2008年第6期394-398,共5页中国病毒学(英文版)
基 金:National Natural Science Foundation of China (30670094,30700028)
摘 要:The molecular modifications of Herpes Simplex Virus Type I (HSV-1) proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/ assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulationThe molecular modifications of Herpes Simplex Virus Type Ⅰ (HSV-1) proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulation.
关 键 词:MODIFICATION Herpes simplex virus type (HSV- 1) Transcriptional regulation
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