The Herpes Simplex Virus Type 1 Multiple Function Protein ICP27  被引量:6

The Herpes Simplex Virus Type 1 Multiple Function Protein ICP27

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作  者:Lei ZHAO Wen-bo ZHU Qiong DING Gui-qing PENG Chun-fu ZHENG 

机构地区:[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

出  处:《Virologica Sinica》2008年第6期399-405,共7页中国病毒学(英文版)

基  金:Start Fund of the Hundred Talents Program of the Chinese Academy of Science (20071010-141);National Natural Science Foundation of China(30870120);Open Research Fund Program of the State Key Laboratory of Virology of China (2007003)

摘  要:The herpes simplex virus type 1 (HSV-1) infected-cell protein 27 (ICP27) is an essential, highly conserved protein involved in various steps of HSV-1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. Recently, many novel functions performed by the HSV- 1 ICP27 protein were shown, including leptomycin B resistance, inhibition of the type I interferon signaling, regulation of the viral mRNA translation and determining the composition of HSV-1 virionsThe herpes simplex virus type 1 (HSV-1) infected-cell protein 27 (ICP27) is an essential,highly conserved protein involved in various steps of HSV-1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. Recently,many novel functions performed by the HSV-1 ICP27 protein were shown,including leptomycin B resistance,inhibition of the type Ⅰ interferon signaling,regulation of the viral mRNA translation and determining the composition of HSV-1 virions.

关 键 词:Herpes simplex virus type 1 (HSV-1) Infected-cell protein 27 (ICP27) Nuclear export LeptomycinB (LMB) Interferon (IFN) 

分 类 号:Q78[生物学—分子生物学] R373.11[医药卫生—病原生物学]

 

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