血压晨峰与冠状动脉病变积分关系的探讨  

A study of the relationship between morning blood pressure surge and coronary artery score

作　　者：王学忠[1] 杨立森[1] 石学宁[1] 方永鹏[1] 林媛豪[1] 贾绍斌[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2008年第11期983-984,共2页Ningxia Medical Journal

摘　　要：目的探讨血压晨峰(morning blood pressure surge,MBPS)与冠状动脉病变积分的关系。方法95例冠心病合并高血压的患者,用药前行动态血压监测,常规Judkins法冠状动脉造影,Gensini积分法(coronary arteryscore,CAS)评价冠状动脉狭窄程度。结果年龄、性别、体重指数(BMI)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)、舒张压(DBP)、脉压指数(PPI)、24小时收缩压标准差(24小时STDs)、24小时最大平均动脉压(24小时MAPmax)及MBPS与CAS相关(r=0.24-0.48,P=0.000-0.049)。多元回归分析显示,PPI、24小时STDs、24小时MAPmax及MBPS与CAS相关(t=2.23-3.47,P=0.011-0.043)。结论PPI、24小时STDs、24小时MAPmax及MBPS与冠状脉狭窄程度相关,MBPS是冠心病高危人群早期干预的一个新的靶点。Objective To explore the relationship between morning blood pressure surge （MBPS） and coronary artery score in patients with primary hypertension and coronary heart disease. Methods Ambulatory blood pressure measurement was recorded and morning blood surge were analyzed in 95 patients （57 males and 38 females） between the age of 45 and 76 （mean 64.4 ± 5.1 ） years old. At the same time coronary angiography were performed and the severity of coronary artery score was calculated. Results Age, sex, BMI, TC, LDL - C, SBP, DBP, PPI, 24h STDs, 24h MAPmax and MBPS were signicantly associated with CAS（r = 0.24 - 0.48, P = 0.000 - 0.049）. Multivariate regression analysis showed that PPI, 24h STDs, 24h MAPmax and MBPS were signicantly associated with CAS （t = 2.23 - 3.47, P = 0.011 - 0. 043 ）. Conclusion PPI, 24h STDs, 24h MAPmax and MBPS are related to the severity of coronary artery stenosis. MBPS is a new target in early intervention for high risk populations of coronary heart disease.

关 键 词：冠状动脉狭窄 血压 血压晨峰 

分 类 号：R541.4[医药卫生—心血管疾病]