HLA-DR基因多态性与广东汉族泛发型白癜风患者的相关性研究  

Polymorphism of HLA-DR in Generalized Vitiligo Patients of Han Nationality in Guangdong

作　　者：刘玉梅[1] 黄振明[1] 何伟强[1] 田歆[1] 毕超[1] 师晋平[1] 

机构地区：[1]广州市皮肤病防治所,广州510095

出　　处：《热带医学杂志》2008年第11期1125-1127,共3页Journal of Tropical Medicine

基　　金：广州市医药卫生科技项目(2006-YB-147)

摘　　要：目的研究广东籍汉族泛发型白癜风患者与HLA-DR的相关性。方法采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,对30例广东籍汉族泛发型白癜风患者和30例健康对照者静脉血样本HLA-DR等位基因多态性进行研究。结果泛发型白癜风患者DRB1*0701等位基因频率显著升高(RR=5.216,Pc<0.05),DRw52(DRB3*0101/02DRB3*0201DRB3*0301)、DRw53(DRB4*0101/03/05)和DRw51(DRB5*0101/02DRB5*0202)基因频率明显低于正常组,以上三者两组间比较均有显著性差异(Pc<0.05)。结论HLA-DRB1*0701等位基因可能与广东籍汉族泛发型白癜风的发病有关,而DRw52(DRB3*0101/02DRB3*0201DRB3*0301)、DRw53(DRB4*0101/03/05)和DRw51(DRB5*0101/02DRB5*0202)对泛发型白癜风发病可能有一定保护作用。Objective To study the HLA-DR genotypes in generalized vitiligo patients of Han Nationality in Guangdong. Methods Venous blood examples from 30 generalized vitiligo patients and 30 normal control subjects of Han Nationality were studied. HLA-DR gene polymorphism was analyzed by PCR-SSP method. Results The frequency of DRB1^＊0701 allele in generalized vitiligo patients was significantly higher than the control subjects （RR=5.216, Pc〈0.05）; while the frequency of DRw52 （DRB3^＊0101/02 DRB3^＊0201 DRB3^＊0301）, DRw53 （DRB4^＊0101/03/ 05）, DRw51 （DRB8^＊0101/02 DRB8^＊0202） was low （adjusted Pc〈0.05）. Conclusion DRB1 ~0701 allele is associated with the occurrence of generalized vitiligo. HLA-DRw52 （DRB3^＊0101/02, DRB3^＊0201, DRB3 ^＊030）, DRw53 （DRB4^＊0101/03/05） and DRw51 （DRB5^＊0101/02 DRBS＊0202） may play a protective role in reducing the incidence of generalized vitiligo.

关 键 词：泛发型白癜风 聚合酶链反应-序列特异性引物技术 HLA—DR 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]