阿克替苷对大鼠试验性前列腺增生模型的抑制作用  

The inhibiting effects of Herba Cistanche on begnin prostatic hyperplasia

作　　者：孙卫东 陈飞[2] 孙云[2] 

机构地区：[1]扬州市中医院,江苏扬州225009 [2]扬州大学医学院,江苏扬州225001

出　　处：《扬州大学学报（农业与生命科学版）》2008年第3期55-58,共4页Journal of Yangzhou University：Agricultural and Life Science Edition

基　　金：江苏省中医药局资助课题(K0110276)

摘　　要：去势大鼠皮下注射丙酸睾酮建立良性前列腺增生模型,阿克替苷[40、20 mg.(kg.d)-1]灌胃4周。光学显微镜观察前列腺细胞结构;免疫组织化学方法检测雄激素受体(AR)和转化生长因子型受体(TGF-β1R)的表达。探讨管花肉苁蓉的化学成分阿克替苷对大鼠实验性前列腺增生模型的抑制作用。结果表明:阿克替苷可明显减轻大鼠前列腺湿重指数,与模型组比较有显著性差异(P<0.01)。高剂量阿克替苷使前列腺上皮细胞AR表达减弱,GFβR1的表达亦减弱,与模型组比较差异显著性(P<0.01)。证明阿克替苷可通过下调AR及TGF-β1R表达抑制上皮细胞增殖,从而抑制大鼠试验性前列腺增生。The BPH rat model was induced by subcutaneous injection of testosterone propionate,and two dose groups of acteoside [40,20 mg（kg·d）^-1] were administrated for 4 weeks,to observe the morphological change of the prostate gland by the microscope.AR and TGF-β1R expressions was examined by the immunity histochemistry.The inhibiting effects of acteoside distilled from Cistanche tubulosa.on begnin prostatic hyperplasia（BPH） were investigated.The acteoside could obviously reduce the prostate gland fresh weight index.Compared with the the model group,the difference was obvious （P〈0.01）.AR and TGF-βR1 expressions reduced in the prostate gland epidermis cell nucleus in high dose group.Compared with the the model group,the difference was obvious（P〈0.01）.Acteoside had the function of inhibiting the experimental models＇BPH.

关 键 词：阿克替苷 大鼠 前列腺增生 AR TGF-β1R 

分 类 号：S858.91[农业科学—临床兽医学]