妊娠合并系统性红斑狼疮的临床分析  

Clinical analysis of pregnancy complicated with systemic lupus erythematosus

作　　者：彭可[1] 

机构地区：[1]广东省惠州市中心人民医院,516001

出　　处：《中国现代药物应用》2008年第23期16-18,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨妊娠与系统性红斑狼疮(SLE)病情的相互影响及SLE患者妊娠时机的选择及妊娠期的处理。方法回顾性调查惠州市中心人民医院收治的31例妊娠合并SLE患者,其中选择性妊娠18例,非选择性妊娠13例,妊娠期予不同剂量泼尼松控制病情。分析比较2组患者妊娠期病情的变化和妊娠的结局。结果选择性妊娠组中6例在孕期出现狼疮活动,非选择性妊娠组的13例均出现较为严重的狼疮并发症。非选择性妊娠组的妊娠丢失率、早产率较选择性妊娠组显著增高(P<0.05),而新生儿存活率及新生儿体质量则较选择性妊娠组显著下降(P<0.05)。结论对妊娠合并SLE患者而言,妊娠和SLE互为不利因素;在SLE病情缓解期选择发妊娠并合理治疗将使母婴安全性明显增高。Objective To investigate the interacting effects between pregnancy and flares of systemic lupus erythematosus （SLE） and to explore the best occasion for SLE patients＇ conception and the management during the pregnancy. Methods Thirty one cases of pregnancy complicated with SLE were investigated retrospectively,among whom 18 were in remission of SLE at the beginning of conception （ Group A） ,and the other 13 either had high-activity of the disease or were first diagnosed as SLE during the pregnancy （ Group B）. Various doses of prednisone were administered to control SLE. Results SLE flares still occurred in 6 cases in Group A, but in all cases in Group B. Compared with Group A, the rates of fetal loss and early delivery were significant- ly higher in Group B （ P 〈 0.05 ）, while the survival rate and the weight of the new born were notably decreased in Group B （P 〈 0. 05 ）. Conclusions Pregnancy and SLE are factors. Selection of remission stage for conception and proper management during the pregnancy could significantly improve the maternal-fetal safety.

关 键 词：妊娠 系统性红斑狼疮 治疗 

分 类 号：R593.241[医药卫生—内科学] R714.255[医药卫生—临床医学]