精子DNA损伤对生殖结局的影响及其临床意义  

Influence of Sperm DNA Damage on Reproductive Outcomes and Its Clinical Significance

作　　者：王晓萌(综述)[1] 刘睿智(审校)[1] 

机构地区：[1]吉林大学白求恩医学院细胞生物学教研室,吉林省生殖医学研究中心,吉林长春130021

出　　处：《中华男科学杂志》2008年第11期1019-1022,共4页National Journal of Andrology

基　　金：吉林省科技厅资助项目(200505140)

摘　　要：多种因素可以导致精子DNA异常,而后者将导致受精结局及胚胎发育质量的异常。越来越多的方法可以检测精子DNA损伤。目前研究认为,与传统检测方法相比,精子DNA损伤的检测可能有着更优越的作用。在IVF及ICSI的应用中,精子DNA损伤检测有其特殊的适应人群,但是其临床应用前景有待进一步研究。Many factors are responsible for sperm DNA damage, which may lead to fertilization failure and embryo maldevelopment. At present, sperm DNA damage can be detected by more and more methods, which are considered to be superior to the conventional measures. There are some clinical indications for tests of sperm DNA damage in IVF/ICSI, but additional studies are still needed to fully define the clinical value of testing sperm DNA damage.

关 键 词：精子 DNA损伤 生殖结局 检测工具 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]