羟基磷灰石与聚乙烯复合材料的组织相容性和骨传导性实验研究  

Experimental study of biocompatible and osteoinductive behavior of hydroxyapatite/polyethylene

作　　者：王乙迪[1] 李冬梅[1] 秦毅[1] 周军[1] 

机构地区：[1]首都医科大学附属北京同仁医院眼科中心,100730

出　　处：《眼科》2008年第6期386-389,共4页Ophthalmology in China

摘　　要：目的探讨羟基磷灰石与聚乙烯复合材料(hydroxyapatite/high-density polyethylene composite,HA/PE)的组织相容性和可塑性。设计实验性研究。研究对象45只新西兰白兔。方法实验动物随机分为HA/PE复合材料、多孔HA材料和多孔PE材料植入组,每组各15只。三组动物分别于眶下缘植入HA/PE复合材料、多孔HA及多孔PE材料三种不同植入物,于术后1、4、8、12、24周行大体、光学显微镜、扫描电镜检查。主要指标植入物愈合及植入物内出现骨组织情况。结果植入物无脱出、移位,与周围组织愈合紧密。HA/PE组术后1周即有成纤维细胞及新生血管长入,术后12周及24周可见成骨细胞、骨细胞等骨组织。HA组术后8周可见成骨细胞,24周孔隙内充满骨细胞。PF组可见成纤维细胞及新生血管长入,未见骨组织。结论HA/PE既具有HA良好的生物相容性及骨传导性,又具有聚乙烯材料良好的可塑性,有望成为较理想的骨替代材料。Objective To explore the histocompatibility and plasticitity of hydroxyapatite/high-density polyethylene composite （HA/PE）. Design Experimental study. Participants Forty-five rabbits. Methods Rabbits were randomly derided into HA/PE, HA and PE surgical groups, every group included 15 rabbits. Osteoectomy of orbital rim and implantation （HA/PE, HA and PE materials were used） were performed on 3 groups of the rabbits. At 1st week, 4th week, 8th week, 12th week and 24th week of postoperation, we took out the samples from the rabbits separately in each group and did histopathologic and electron microscope examinations. Main Outcome Measures Physical signs of the implant combination with the bone. The bone cell appeared in the implants. Results After 12 weeks, the calcium salts deposit like bone plate with some osteoblast inside the HA/PE implants was observed. After 8 weeks, the calcium salts deposit inside the HA plants was observed. In the PE implants, nothing could be seen but some fibrous connective tissue. Conclusion HA/PE is an ideal repair material especially for orbital bone.

关 键 词：羟基磷灰石复合材料 眼眶成形 组织相容性 

分 类 号：TB332[一般工业技术—材料科学与工程]