大鼠腰骶髓后连合核内P物质受体阳性神经元与GABA能轴突终末的突触联系  

GABA ergic SYNAPSES ON SUBSTANCE P RECEPTOR EXPRESSING NEURONS IN THE DORSAL COMMISSURAL NUCLEUS OF THE RAT

作　　者：吕岩[1] 丁玉强[1] 王丹[1] 龚良维[1] 秦秉志[1] 李继硕[1] 

机构地区：[1]第四军医大学解剖学教研室

出　　处：《解剖学报》1997年第4期355-358,I004,共5页Acta Anatomica Sinica

摘　　要：用包埋前免疫组织化学方法结合包埋后免疫金电镜技术，研究了大鼠腰骶髓后连合核内Ｐ物质受体（ＳＰＲ）免疫反应神经元与ＧＡＢＡ能终末的突触联系。ＳＰＲ免疫反应产物主要分布于神经元胞体和树突的胞膜下。双重标记电镜结果表明，约有４６％的ＳＰＲ阳性树突和胞体与ＧＡＢＡ能终末形成对称性突触。其中绝大部分为轴树突触，个别为轴体突触。本研究结果提示，大鼠腰骶髓后连合核ＳＰＲ阳性神经元可能接受ＧＡＢＡ能终末的调控。mploying pre embedding immunocytochemical detection of SPR combined with post embedding technique to identify GABA immunoreactivity, we examined whether GABA ergic axon terminals form synaptic contacts with neurons expressing substance P receptor in the dorsal commissural nucleus (DCN) of the rat. SPR immunoreactive productrs in the DCN neurons were seen not only in the postsynaptic sites, but also in the nonsynaptic regions of the perikaryal and dendritic profiles. In the doubly immunostained sections, about 46% of SPR immunoreactive dendrites were in the symmetric synaptic contacts with GABA ergic axon terminals. These results suggest that the neurons expressing SPR in the DCN may receive inhibitory modulation through GABA.

关 键 词：P物质受体 GABA 脊髓 腰骶段 神经元 

分 类 号：R338.13[医药卫生—人体生理学] R329.48[医药卫生—基础医学]