可缓释药物的明胶/磷酸钙骨水泥复合组织工程支架材料  

Gelatin/calcium phosphate cement composite scaffold with drug release ability for bone tissue engineering

作　　者：谭红香[1,2] 叶建东[1,2] 董浩[3] 

机构地区：[1]华南理工大学特种功能材料教育部重点实验室,广州510640 [2]华南理工大学材料学院,广州510640 [3]国家烟草质量监督检验中心,郑州450001

出　　处：《复合材料学报》2008年第6期77-81,共5页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金资助项目(50772037);广东省自然科学基金资助项目(04205786)

摘　　要：采用向孔隙中灌注含聚乳酸-聚乙醇酸共聚物(PLGA)载药微球的明胶溶液的方法制备了具有药物缓释功能的明胶/磷酸钙骨水泥复合组织工程支架。用扫描电子显微镜观察了微球和支架的形貌特征,用万能材料试验机测定了支架材料的抗压强度,用紫外-可见分光光度计分析了复合支架的释药率。结果表明,灌注明胶对多孔磷酸钙骨水泥支架起到显著的增强作用,抗压强度达2.42 MPa。复合支架携载硫酸庆大霉素,具有良好的药物缓释功能,缓释时间可达30天以上,使支架在修复骨缺损的同时能消除炎症反应,成为一种集骨修复和治疗于一体的新型组织工程支架材料,具有良好的应用前景。The gelatin/calcium phosphate cement （CPC） composite scaffold with antibiotic release ability for bone tissue engineering was prepared by infiltration of gelatin solution containing the gentamicin sulphate （GS）-entrapped poly （lactic-co-glyeolic acid） （PLGA） microspheres into the macropores of the CPC scaffold. The morphologies of the microspheres and scaffold were observed by an electron scanning microscope, and the compressive strength and drug release of the scaffold were determined with a universal testing machine and an ultraviolet- visible spectrophotometer, respectively. The results indicate that the composite scaffold is significantly enhanced by the gelatin infiltration and a satisfying compressive strength of 2. 42 MPa is achieved. The release of GS from the scaffold lasted for over 30 days, indicating a good drug release ability. This composite scaffold is a novel tissue engineering scaffold providing dual functions of bone-repairing and infection-diminishing with promising application prospects.

关 键 词：磷酸钙骨水泥 支架 PLGA微球 硫酸庆大霉素 明胶 

分 类 号：TB332[一般工业技术—材料科学与工程]