替米沙坦对高脂饮食大鼠肥胖和血脂水平的影响  

Effects of Telmisartan on obesity and serum lipids of rats fed with high-fat diet

作　　者：李焱[1] 蒋妍[1] 刘珊英[1] 黎锋[1] 萧辉盛[1] 刘丹[1] 严励[1] 傅祖植[1] 

机构地区：[1]中山大学附属第二医院内分泌科,广东广州510120

出　　处：《国际内科学杂志》2008年第11期621-624,共4页International Journal of Internal Medicine

摘　　要：目的探讨运用替米沙坦阻断肾素-血管紧张素系统(RAS)对大鼠肥胖和血脂水平的影响。方法40只雄性SD大鼠随机分为对照组、对照治疗组、高脂组、高脂治疗组,分别用正常饮食、正常饮食联合替米沙坦、高脂饮食、高脂饮食联合替米沙坦处理。各组大鼠体质量每周测量一次,喂养10周后取大鼠静脉血检测血脂,测量内脏脂肪质量,计算Lee’s指数。结果高脂饮食组大鼠平均体质量随时间变化的趋势显著高于对照组和高脂治疗组(P=0.046,P=0.035)。高脂治疗组大鼠平均体质量的增加和平均内脏脂肪质量均显著低于高脂组(P=0.012,P=0.024)。高脂治疗组大鼠平均甘油三酯(TG)水平显著低于高脂组(P=0.002),但平均高密度脂蛋白胆固醇(HDL-c)水平显著高于高脂组(P=0.023)。结论替米沙坦可以抑制大鼠高脂饮食引起的肥胖,同时改善高脂饮食引起的血脂紊乱。Objective To study the effect of Telmisartan on obesity and serum lipids of SD rats fed with high-fat diet. Methods Forty SD rats were randomly divided into control group, control and treatment group, high-fat diet group , high-fat diet and treatment group, which were treated with normal diet, normal diet and gastric perfusion of Telmisartan, high-fat diet, high-fat diet and gastric perfusion of Telmisartan respectively. Body weight of the rats were recorded weekly. The serum lipids and the weight of epididymides and retroperitoneal adipose tissue were measured ten weeks later, then Leeg index was calculated. Results The body weight of rats in high-fat diet group was significantly higher than that of rats in control group, high-fat diet and treatment group（P =0. 046, P =0. 035）. The increase of body weight and visceral adipose mass of rats in the high-fat diet group were significantly higher than that of rats in high-fat diet and treatment group （P = 0. 012, P = 0. 024）. The level of triglyceride（TG） was significantly higher in the high-fat diet group than the high-fat diet and treatment group （ P = 0. 002 ） , but the level of high-density lipoprotein cholesterol （ HDL-c ） was significantly lower in the high-fat diet group than the high-fat diet treated group （ P = O. 023 ）. Conclusions Telmisartan can inhibit the increase of body weight of SD rats induced by high-fat diet ,and improve the serum lipid disorders simultaneously.

关 键 词：血管紧张素Ⅱ受体拮抗剂 体质量 血脂 

分 类 号：R59[医药卫生—内科学]