冠心病患者肱-踝脉搏波传导速度与颈动脉内中膜厚度相关性的研究  

Relationship between brachial-ankle pulse wave velocity and carotid intima media thickness in patients with coronary heart disease

作　　者：杜丽根[1] 邱健[1] 阮云军[1] 董凤英[1] 徐琳[1] 洪长江[1] 马骏[1] 

机构地区：[1]广州军区总医院心血管内科,510010

出　　处：《重庆医学》2008年第23期2655-2656,2659,共3页Chongqing medicine

基　　金：广东省科技计划项目资助(2007B060401046)

摘　　要：目的通过研究冠心病患者肱-踝脉搏波传导速度(baPWV)与颈动脉内中膜厚度(cIMT)的变化及相关性,探讨动脉硬化和动脉粥样硬化之间的相关性。方法本研究入选102例在本院行冠脉造影的患者,按冠脉造影的结果分为对照组和冠心病组,冠心病组根据冠脉病变程度进一步分为单支、双支、多支病变组。所有入选者在冠脉造影前用日本欧姆龙科林一起同步记录两侧baPWV,用超声检测cIMT。结果冠心病组baPWV、cIMT明显高于对照组,差异有统计学意义(P<0.05);冠状动脉病变程度分析中baPWV、cIMT随着冠脉病变程度加重均有增高趋势,其中多支病变、双支病变组baPWV和cIMT均高于单支病变组、对照组,单支病变组baPWV明显高于对照组,差异有统计学意义(P<0.05)。将选入的患者baPWV和cIMT做直线相关分析,结果呈正相关(r=0.451,P<0.001)。在控制了吸烟、高血压病史、糖尿病史等多种动脉粥样硬化危险因素后,这种相关性仍然存在(r=0.391,P<0.01)。结论baPWV和cIMT密切相关,在一定程度上说明动脉硬化与动脉粥样硬化可能存在相关性。Objective By detecting brachial-ankle pulse wave velocity and carotid intima media thickness in the patients with cor onary heart disease,to investigate the relationship between coronary stiffness and coronary artherosclerosis. Methods One hundred and two patients who were performed by coronary angiography（CAG） were divided into two groups according to the result of CAG：coronary heart disease group and control group. Coronary heart disease group was divided into single-vessel group, dual vessel group and multiple-vessel group in term of the extent of coronary artery. Brachial ankle artery pulse wave velocity （baPWV） was measure by a Colin system,cIMT was detected by Doppler echocardiographic examination. Results baPWV and cIMT were significantly higher in coronary heart disease group compared with those in control group. In the analysis of the degree of coronary artery disease,baPWV and cIMT increased gradually with the extent of coronary artery, baPWV and cIMT in those with multiple-vessel disease group and dual-vessel disease group were respectively higher than those with single-vessel disease group and control group. baPWV in those with single-vessel disease group was significantly higher than those in control group （P〈0.05）. baPWV was correlated to cIMT （r=0. 451 ,P〈0. 001）. The relation also existed after controlling the risk factors of the atherosclerosis such as eig arette, hyperpiesia and diabetes（r= 0.391, P〈0.01）. Conclusion baPWV is strongly related with cIMT, to some extentt may illustrate that there may have relationship between coronary stiffness and coronary artherosclerosis.

关 键 词：动脉硬化 动脉粥样硬化 肱踝脉搏波传导速度 颈动脉内中膜厚度 

分 类 号：R541.4[医药卫生—心血管疾病] R543.4[医药卫生—内科学]