夜香树提取物体内抗肿瘤作用的实验研究  

Experimental Study on Antitumor Effect of Extracts from Cestrum nocturnum in vivo

作　　者：钟振国[1] 赵世元[2] 吕金燕[1] 李鹏[1] 

机构地区：[1]广西中医学院新药研究开发中心,广西南宁530001 [2]广西民族医院,广西南宁530001

出　　处：《中药材》2008年第11期1709-1712,共4页Journal of Chinese Medicinal Materials

基　　金：广西科技攻关项目(0816004-17)

摘　　要：目的:观察夜香树提取物小鼠体内抗肿瘤作用。方法:以S180肉瘤H22肝癌作为实验瘤株,观察夜香树提取物中正丁醇部位、多糖部位对S180小鼠肉瘤抑瘤率,对H22腹水型肝癌进行肿瘤生存期试验。结果:夜香树提取物正丁醇部位和多糖部位明显抑制S180和H22小鼠体内肿瘤的发生和发展,剂量30、20、15 mg/kg的抑瘤率分别为52.30%、46.75%、42.28%和43.19%、37.96%、31.82%;夜香树提取物正丁醇部位和多糖部位能显著提高H22腹水瘤小鼠的生命延长率,生命延长率分别达到116.43%、44.52%、20.54%和109.52%、112.61%、115.01%。夜香树提取物正丁醇部位抑瘤作用与剂量呈正相关关系,而多糖部位抑瘤效果与剂量关系不明显。结论:夜香树提取物体内试验能延缓荷瘤小鼠的瘤体生长,明显延长荷瘤小鼠的生存期。Objective ： To observe the antitumor effects of extracts from Cestrum nocturnum （CN） in vivo. Methods ： The S180-mice model was used to observe the tumor-inhibition rate of CN and the H22-mice model was used to test the survival time. Results：The experiment in S180-mice demonstrated that the n-butanol and polysaccharides extracts from CN had obvious effects on tumor inhibition. Its inhibitory rates were 52. 30% ,46. 75% ,42. 28% ,43. 19% ,37. 96% and 31.82% respectively in the mice administrated the n-butanol and polysaccharides extracts from CN with 30mg/kg,20mg/kg and 15mg/kg weight dosage. It was noted that tumor formation postponed in mice treated with the n-butanol and polysaccharides extracts from CN compared with the control panel and tumor growth became slower;The n-butanol and polysaccharides extracts from CN could also greatly enhance the life span of mice with H22 ascitic tumors by 116. 43% ,44. 52% ,20. 54%, 109. 52%, 112.61% and 115.01%, respectively. The inhibit effects of n-butanol fraction extracts from CN had direct relationship with dose, while the polysaccharides fraction extracts from CN had no obvious relationship with dose. Conclusion：The n-butanol and polysaccharides extracts of CN are able to inhibit tumor growth and prolong the lifetime of the tumor-bearing mice in a dose-dependent pattern.

关 键 词：夜香树提取物 抗肿瘤作用 体内抑瘤 

分 类 号：R285.5[医药卫生—中药学]