HEMA／NIPAAm栓塞颅底血管网的动物实验研究  

Embolization of AVM with HEMA/NIPAAm：an experimental study

作　　者：肖福顺[1] 宁志芬[2] 李牧[1] 陈光[1] 冯学泉[1] 王嵩[1] 刘文广[3] 代凤英[3] 

机构地区：[1]天津医科大学一中心临床学院神经外科,300192 [2]天津医科大学生物学教研室 [3]天津大学材料科学与工程学院

出　　处：《中华神经外科杂志》2008年第11期876-878,共3页Chinese Journal of Neurosurgery

基　　金：国家自然科学基金资助项目（50573054）;天津市自然科学基金资助项目（07JCYBJC02800）

摘　　要：目的探讨温度敏感型甲基丙烯酸-2-羟乙酯／N-异丙基丙烯酰胺（HEMA／NIPAAm）嵌段共聚物栓塞AVM的动物模型的可行性；评价其栓塞效果及病理改变。方法选取实验用猪16只。应用微导管超选择性导人猪的颅底血管网（RMB）。注射1：1浓度的HEMA／NIPAAm嵌段共聚物、欧乃培克混合物直至RMB完全不显影为止。于术后急慢性期进行造影及病理组织学观察。结果HEMA／MPAAm嵌段共聚物在畸形团内弥散和铸型良好，无粘管。血管造影复查未见血管再通。病理检查可见血管团的血管结构消失，周罔有异物巨细胞浸润。结论HEMA／MPAAm嵌段共聚物栓塞AVM具有弥散佳、无粘管、容易控制、不受注射时间限制、无再通等特点。可以作为临床应用。Objective To study the feasibility of embolization AVM with HEMA/NIPAAm in swine models. To observe the clinical effects and histopathological changes after embolization AVM with HEMA/ NIPAAm. Method 16 swine were used for the HEMA/NIPAAm embolization in this study. Seldinger＇s techniques were used and micro-catheters were induced to the swine fete mirabile（RMB） ,embolization RMB with HEMA/NIPAAm through micro-catheters. Angiographic and histopathological evaluations were made at 3days,14 days,1 month,3 months and 6 months after the embolization procedure. Results There was no difficulty in delivering HEMA/NIPAAm through micro-catheters, the injection time was more than 1 hour and no occurrence of catheter ＂gluing＂. The mixture could well diffuse into the RMB and form a cast. There was no angiographic recanalization at follow-up. Main patbological changes were scattered inflammation response manifested by the foreign body giant cell teaction. Conclusions Temperature-varied Material （HEMA/ NIPAAm）was a new embolization material, it could well diffuse into the RMB and form a east, without catheter ＂gluing＂, no angiographic recanalization at follow-up. It can be used in clinic.

关 键 词：中枢神经系统血管畸形 温度敏感型 栓塞材料 栓塞 

分 类 号：R686[医药卫生—骨科学]